Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | NPY1R | P25929 | 1/20 | 0.44 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.44 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14334349 | 0.89 | KEAP1 (0.48) | SMN1; SMN2LMNAKEAP1HTTALDH1A1 | |
| SCHEMBL14992892 | 0.89 | SMN1; SMN2 (0.47) | SMN1; SMN2LMNAHTTALDH1A1LOXL2 | |
| SCHEMBL4508326 | 0.89 | CYP19A1 (0.50) | SMN1; SMN2HTTALDH1A1LOXL2NPY1R | |
| SCHEMBL15819472 | 0.88 | HTT (0.50) | SMN1; SMN2LMNAHTTALDH1A1CA12 | |
| SCHEMBL15643222 | 0.85 | ADAMTS4 (0.51) | SMN1; SMN2ALDH1A1MCL1ADAMTS4MMP13 | |
| SCHEMBL15841261 | 0.84 | HTT (0.48) | SMN1; SMN2LMNAHTTALDH1A1LOXL2 | |
| SCHEMBL14334121 | 0.83 | CYP19A1 (0.48) | SMN1; SMN2LMNAKEAP1HTTALDH1A1 | |
| SCHEMBL15643545 | 0.82 | CYP19A1 (0.44) | SMN1; SMN2LMNAHTTALDH1A1NPY1R | |
| SCHEMBL14992486 | 0.81 | PRMT1 (0.43) | SMN1; SMN2HTTALDH1A1NPY1RNPY5R | |
| SCHEMBL14993097 | 0.80 | ADAMTS4 (0.45) | SMN1; SMN2LMNAHTTALDH1A1NPY1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2721006-A1 | HETEROCYCLIC COMPOUNDS FOR TREATING HELMINTH INFECTIONS | E. I. Du Pont de Nemours and Company (US) | 2014-04-23 | — | — | EP | claimed |
| WO-2012177668-A1 | HETEROCYCLIC COMPOUNDS FOR TREATING HELMINTH INFECTIONS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2012-12-27 | — | — | WO | claimed |
| EP-2721006-A1 | HETEROCYCLIC COMPOUNDS FOR TREATING HELMINTH INFECTIONS | E. I. Du Pont de Nemours and Company (US) | 2014-04-23 | — | — | EP | disclosed |
| WO-2012177668-A1 | HETEROCYCLIC COMPOUNDS FOR TREATING HELMINTH INFECTIONS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2012-12-27 | — | — | WO | disclosed |