Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.41 |
| ▸ | PTGES | O14684 | 2/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15643340 | 0.90 | ALDH1A1 (0.42) | CYP19A1HTTSMN1; SMN2MAPTCYP1A2 | |
| SCHEMBL14992486 | 0.87 | PRMT1 (0.43) | HTTSMN1; SMN2ALDH1A1POLBNPY1R | |
| SCHEMBL14334759 | 0.84 | AR (0.53) | CYP19A1HTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL14993097 | 0.84 | ADAMTS4 (0.45) | HTTSMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL14992699 | 0.83 | NPY1R (0.44) | HTTSMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL14333772 | 0.82 | SMN1; SMN2 (0.53) | HTTSMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL4508326 | 0.80 | CYP19A1 (0.50) | CYP19A1HTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL14992892 | 0.80 | SMN1; SMN2 (0.47) | HTTSMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL15819557 | 0.80 | MAPT (0.45) | CYP19A1HTTSMN1; SMN2MAPTCYP1A2 | |
| SCHEMBL15643247 | 0.79 | CYP19A1 (0.48) | CYP19A1HTTSMN1; SMN2GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140113934-A1 | HETEROCYCLIC COMPOUNDS FOR TREATING HELMINTH INFECTIONS | E I DU PONT DE NEMOURS AND COMPANY (US) | 2014-04-24 | — | — | US | claimed |
| US-20140113934-A1 | HETEROCYCLIC COMPOUNDS FOR TREATING HELMINTH INFECTIONS | E I DU PONT DE NEMOURS AND COMPANY (US) | 2014-04-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140113934-A1 | HETEROCYCLIC COMPOUNDS FOR TREATING HELMINTH INFECTIONS | NR5A2, NR2C2, NPY5R | CYP19A1 686/4885HTT 2978/4885SMN1; SMN2 1669/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.