Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.46 |
| ▸ | RELA | Q04206 | 2/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | STAT3 | P40763 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14342571 | 0.89 | PTGS2 (0.68) | PTGS2KDM4EHPGDLMNACYP1A2 | |
| SCHEMBL14342570 | 0.81 | PTGS2 (0.46) | PTGS2MAPTNFKB1RELAAPP | |
| SCHEMBL14342572 | 0.80 | PTGS2 (0.87) | PTGS2KDM4EHPGDLMNACYP1A2 | |
| SCHEMBL1793302 | 0.80 | PTGS2 (0.87) | PTGS2KDM4EHPGDLMNACYP1A2 | |
| SCHEMBL1793300 | 0.80 | PTGS2 (0.87) | PTGS2KDM4EHPGDLMNACYP1A2 | |
| SCHEMBL1793303 | 0.80 | PTGS2 (0.87) | PTGS2KDM4EHPGDLMNACYP1A2 | |
| SCHEMBL27766349 | 0.75 | KDM4E (0.54) | PTGS2KDM4EHPGDLMNACYP1A2 | |
| SCHEMBL1790052 | 0.73 | APP (0.88) | PTGS2MAPTNFKB1RELAAPP | |
| SCHEMBL1790054 | 0.73 | APP (0.88) | PTGS2MAPTNFKB1RELAAPP | |
| SCHEMBL29799041 | 0.72 | PTGS2 (0.65) | PTGS2KDM4ELMNAALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9724333-B2 | Pyrazole derivative | GREEN TECH CO., LTD. (JP) | 2017-08-08 | — | — | US | disclosed |
| US-20160228412-A1 | NOVEL PYRAZOLE DERIVATIVE | GREEN TECH CO., LTD. (JP) | 2016-08-11 | — | — | US | disclosed |
| US-9321752-B2 | Pyrazole derivative | GREEN TECH CO., LTD. (JP) | 2016-04-26 | — | — | US | disclosed |
| US-20150252029-A1 | Novel Pyrazole Derivative | GREEN TECH CO., LTD. (JP) | 2015-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160228412-A1 | NOVEL PYRAZOLE DERIVATIVE | PSEN2, PSEN1, MAPT | PTGS2 3267/4885KDM4E 4095/4885HPGD 1561/4885 |
| US-20150252029-A1 | Novel Pyrazole Derivative | PSEN2, PSEN1, MAPT | PTGS2 3267/4885KDM4E 4095/4885HPGD 1561/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.