Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | ELANE | P08246 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14344821 | 1.00 | POLB (0.37) | POLBELANEMEN1KMT2ACYP3A4 | |
| SCHEMBL14344878 | 0.85 | LIG1 (0.34) | POLBMEN1KMT2ALMNAL3MBTL1 | |
| SCHEMBL14344894 | 0.85 | LIG1 (0.34) | POLBMEN1KMT2ALMNAL3MBTL1 | |
| SCHEMBL14344983 | 0.84 | KDM4E (0.37) | POLBMEN1KMT2ACYP3A4LMNA | |
| SCHEMBL8746478 | 0.80 | ELANE (0.49) | POLBELANEMEN1KMT2AL3MBTL1 | |
| SCHEMBL7776782 | 0.80 | ELANE (0.49) | POLBELANEMEN1KMT2AL3MBTL1 | |
| SCHEMBL14344962 | 0.73 | ELANE (0.38) | POLBELANEMEN1KMT2ALMNA | |
| SCHEMBL4168099 | 0.71 | ALDH1A1 (0.38) | POLBELANEMEN1KMT2ALMNA | |
| SCHEMBL5568919 | 0.70 | FOLH1 (0.38) | POLBELANEMEN1KMT2ACYP3A4 | |
| SCHEMBL6533837 | 0.70 | FOLH1 (0.38) | POLBELANEMEN1KMT2ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312240-B2 | Conformationally constrained paclitaxel analogs and their use as anticancer and anti-Alzheimers agents | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (US) | 2007-12-25 | — | — | US | disclosed |