Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5332987 | 0.86 | L3MBTL1 (0.54) | MAPK1L3MBTL1TDP1KDM4EMAPT | |
| SCHEMBL6006626 | 0.72 | MEN1 (0.57) | KDM4EMAPTHTTMEN1KMT2A | |
| SCHEMBL4864913 | 0.70 | MEN1 (0.59) | MAPK1L3MBTL1KDM4EMAPTMEN1 | |
| SCHEMBL10621375 | 0.70 | EED (0.52) | MAPK1L3MBTL1TDP1KDM4EMAPT | |
| SCHEMBL4870805 | 0.69 | HTR2A (0.63) | MAPK1L3MBTL1KDM4EMAPTMEN1 | |
| SCHEMBL7345342 | 0.67 | ALDH1A1 (0.67) | L3MBTL1TDP1KDM4EMAPTHTT | |
| SCHEMBL10192165 | 0.67 | NOTUM (0.64) | KDM4EMAPTMEN1KMT2ANPC1 | |
| SCHEMBL4026091 | 0.66 | KDM4E (0.71) | KDM4EMAPTHTTMEN1KMT2A | |
| SCHEMBL156256 | 0.66 | NOTUM (0.82) | KDM4EMAPTHTTMEN1KMT2A | |
| SCHEMBL8759278 | 0.66 | MEN1 (0.66) | MAPK1L3MBTL1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007146230-A2 | NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS | MERCK & CO., INC. (US) | 2007-12-21 | — | — | WO | disclosed |