Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 2/20 | 0.33 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.33 |
| ▸ | ECE1 | P42892 | 1/20 | 0.31 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.31 |
| ▸ | NOTCH1 | P46531 | 1/20 | 0.31 |
| ▸ | RBPJ | Q06330 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | PPARD | Q03181 | 1/20 | 0.31 |
| ▸ | PPARA | Q07869 | 1/20 | 0.31 |
| ▸ | FCER2 | P06734 | 1/20 | 0.30 |
| ▸ | MMP1 | P03956 | 1/20 | 0.30 |
| ▸ | MMP2 | P08253 | 1/20 | 0.30 |
| ▸ | MMP3 | P08254 | 1/20 | 0.30 |
| ▸ | MMP7 | P09237 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8427682 | 1.00 | GRIK1 (0.33) | GRIK1GRIK2ECE1CAPN1NOTCH1 | |
| SCHEMBL14348063 | 0.84 | MMP2 (0.43) | NOTCH1RBPJMMP1MMP2MMP3 | |
| SCHEMBL8427651 | 0.84 | MMP2 (0.43) | NOTCH1RBPJMMP1MMP2MMP3 | |
| SCHEMBL8426501 | 0.81 | CTSK (0.32) | — | |
| SCHEMBL14348085 | 0.81 | CTSK (0.32) | — | |
| SCHEMBL8235462 | 0.81 | MMP1 (0.34) | GRIK1GRIK2FCER2MMP1MMP2 | |
| SCHEMBL14117556 | 0.81 | MMP1 (0.34) | GRIK1GRIK2FCER2MMP1MMP2 | |
| SCHEMBL14375169 | 0.81 | CTSK (0.32) | — | |
| SCHEMBL14347675 | 0.81 | ECE1 (0.32) | GRIK1GRIK2ECE1 | |
| SCHEMBL13913518 | 0.81 | ECE1 (0.32) | GRIK1GRIK2ECE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7304056-B2 | Succinoylamino lactams as inhibitors of Aβ protein production | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2007-12-04 | — | — | US | disclosed |
| US-7304049-B2 | Succinoylaminobenzodiazepines as inhibitors of Aβ protein production | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2007-12-04 | — | — | US | disclosed |