Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.54 |
| ▸ | PARP1 | P09874 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 15/20 | 0.49 |
| ▸ | LMNA | P02545 | 9/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.46 |
| ▸ | MEN1 | O00255 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1435318 | 0.87 | CYP1B1 (0.54) | CYP1B1PARP1MAPTLMNASMN1; SMN2 | |
| SCHEMBL1435687 | 0.87 | MAPT (0.60) | CYP1B1PARP1MAPTLMNASMN1; SMN2 | |
| SCHEMBL1435433 | 0.87 | TP53 (0.53) | PARP1MAPTLMNASMN1; SMN2KDM4E | |
| SCHEMBL1435414 | 0.84 | MAOB (0.56) | CYP1B1PARP1MAPTLMNASMN1; SMN2 | |
| SCHEMBL1435404 | 0.84 | MAPT (0.56) | CYP1B1PARP1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL1435550 | 0.83 | CYP1B1 (0.57) | CYP1B1PARP1MAPTLMNASMN1; SMN2 | |
| SCHEMBL31401011 | 0.77 | LMNA (0.55) | MAPTLMNASMN1; SMN2KDM4EKMT2A | |
| SCHEMBL28479905 | 0.76 | MAPT (0.50) | PARP1MAPTLMNASMN1; SMN2KDM4E | |
| SCHEMBL1435357 | 0.76 | HTR2C (0.52) | CYP1B1PARP1MAPTLMNAKDM4E | |
| SCHEMBL1435504 | 0.76 | MAPT (0.54) | MAPTLMNAMAPK1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1898908-B1 | NOVEL CHEMICAL COMPOUNDS AND THE USES THEREOF AS A MEDICAMENT | TROPHOS (FR) | 2011-03-30 | — | — | EP | claimed |
| EP-1898908-B1 | NOVEL CHEMICAL COMPOUNDS AND THE USES THEREOF AS A MEDICAMENT | TROPHOS (FR) | 2011-03-30 | — | — | EP | disclosed |
| EP-1898908-A2 | NOVEL CHEMICAL COMPOUNDS AND THE USES THEREOF AS A MEDICAMENT | Trophos (FR) | 2008-03-19 | — | — | EP | disclosed |
| WO-2007003767-A2 | NOVEL CHEMICAL COMPOUNDS AND THE USES THEREOF AS A MEDICINE | TROPHOS (FR) | 2007-01-11 | — | — | WO | disclosed |