Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.35 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7844569 | 0.77 | ALDH1A1 (0.43) | ALDH1A1PKMKMT2AMEN1LMNA | |
| SCHEMBL29556927 | 0.66 | ALDH1A1 (0.59) | ALDH1A1TRIM24TRIM33KMT2AMEN1 | |
| SCHEMBL20448823 | 0.66 | ALDH1A1 (0.59) | ALDH1A1TRIM24TRIM33KMT2AMEN1 | |
| SCHEMBL78873 | 0.66 | ALDH1A1 (0.59) | ALDH1A1TRIM24TRIM33KMT2AMEN1 | |
| Benzene SCHEMBL28103329 | 0.66 | ALDH1A1 (0.59) | ALDH1A1TRIM24TRIM33KMT2AMEN1 | |
| SCHEMBL19020647 | 0.65 | L3MBTL1 (0.53) | ALDH1A1ACHEKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL29951511 | 0.64 | LMNA (0.52) | ALDH1A1TRIM24TRIM33KMT2AMEN1 | |
| SCHEMBL30175586 | 0.64 | ALDH1A1 (0.56) | ALDH1A1TRIM24TRIM33KMT2AMEN1 | |
| SCHEMBL30175585 | 0.64 | ALDH1A1 (0.56) | ALDH1A1TRIM24TRIM33KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL7536438 | 0.64 | ALDH1A1 (0.56) | ALDH1A1TRIM24TRIM33KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007144579-A1 | N-OXIDES OF DIARYLUREA DERIVATIVES AND THEIR USE AS CHK1 INHIBITORS FOR THE TREATMENT OF CANCER | SENTINEL ONCOLOGY LIMITED (GB) | 2007-12-21 | — | — | WO | disclosed |