Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.55 |
| ▸ | MAPT | P10636 | 10/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1435550 | 0.83 | CYP1B1 (0.57) | RAB9AMAPTNPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL1756267 | 0.81 | MAPT (0.61) | RAB9AMAPTNPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL1435500 | 0.81 | MAPT (0.47) | RAB9AMAPTNPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL27908151 | 0.80 | ALDH1A1 (0.65) | RAB9AMAPTNPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL4099208 | 0.77 | MAPT (0.60) | RAB9AMAPTNPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL1756326 | 0.76 | RAB9A (0.63) | RAB9AMAPTNPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL1067495 | 0.76 | MAPT (0.55) | RAB9AMAPTNPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL11491739 | 0.73 | MAPT (0.67) | RAB9AMAPTNPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL4307134 | 0.73 | MAPT (0.67) | RAB9AMAPTNPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL8685929 | 0.71 | MAPT (0.69) | RAB9AMAPTNPC1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1898908-B1 | NOVEL CHEMICAL COMPOUNDS AND THE USES THEREOF AS A MEDICAMENT | TROPHOS (FR) | 2011-03-30 | — | — | EP | claimed |
| EP-1898908-B1 | NOVEL CHEMICAL COMPOUNDS AND THE USES THEREOF AS A MEDICAMENT | TROPHOS (FR) | 2011-03-30 | — | — | EP | disclosed |