Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 8/20 | 0.64 |
| ▸ | RAB9A | P51151 | 6/20 | 0.58 |
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | AR | P10275 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | C1S | P09871 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1756267 | 0.87 | MAPT (0.61) | ALDH1A1SMN1; SMN2MAPTRAB9ANPC1 | |
| SCHEMBL7444589 | 0.83 | CSNK2A1 (0.59) | ALDH1A1SMN1; SMN2MAPTRAB9ALMNA | |
| SCHEMBL1435582 | 0.80 | RAB9A (0.55) | ALDH1A1SMN1; SMN2MAPTRAB9ANPC1 | |
| SCHEMBL1068291 | 0.80 | MAPT (0.97) | ALDH1A1SMN1; SMN2MAPTRAB9ANPC1 | |
| SCHEMBL6687941 | 0.80 | LTA4H (0.61) | ALDH1A1SMN1; SMN2MAPTLMNAMEN1 | |
| SCHEMBL1067495 | 0.79 | MAPT (0.55) | ALDH1A1SMN1; SMN2MAPTRAB9ANPC1 | |
| SCHEMBL1756326 | 0.79 | RAB9A (0.63) | ALDH1A1SMN1; SMN2MAPTRAB9ANPC1 | |
| SCHEMBL11491739 | 0.78 | MAPT (0.67) | ALDH1A1SMN1; SMN2MAPTRAB9ANPC1 | |
| SCHEMBL4640043 | 0.78 | ALOX5 (0.59) | ALDH1A1SMN1; SMN2MAPTRAB9ANPC1 | |
| SCHEMBL7437902 | 0.78 | LMNA (0.61) | ALDH1A1SMN1; SMN2MAPTRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102947280-A | Carboxy-oxazole or thiazole compounds as DGAT-1 inhibitors useful for the treatment of obesity | PIRAMAL LIFE SCIENCES LTD | 2013-02-27 | — | — | CN | disclosed |