Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.43 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.43 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14357156 | 0.90 | ADORA2B (0.41) | ALDH1A1KMT2ASMN1; SMN2TDP1NPC1 | |
| SCHEMBL14357144 | 0.88 | SMN1; SMN2 (0.44) | ALDH1A1KMT2ASMN1; SMN2TAS1R3TAS1R1 | |
| SCHEMBL14357183 | 0.86 | KMT2A (0.44) | ALDH1A1KMT2ASMN1; SMN2TAS1R3TAS1R1 | |
| SCHEMBL14357182 | 0.86 | SMN1; SMN2 (0.42) | ALDH1A1KMT2ASMN1; SMN2TAS1R3TAS1R1 | |
| SCHEMBL14357184 | 0.86 | SMN1; SMN2 (0.42) | ALDH1A1KMT2ASMN1; SMN2TAS1R3TAS1R1 | |
| SCHEMBL14357170 | 0.84 | KDM4E (0.44) | ALDH1A1KMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL14357165 | 0.83 | SMN1; SMN2 (0.42) | ALDH1A1KMT2ASMN1; SMN2TAS1R3TAS1R1 | |
| SCHEMBL4396396 | 0.83 | ALDH1A1 (0.45) | ALDH1A1KMT2ATDP1NPC1RAB9A | |
| SCHEMBL14357158 | 0.83 | NAMPT (0.48) | ALDH1A1KMT2ASMN1; SMN2TAS1R3TAS1R1 | |
| SCHEMBL14357176 | 0.82 | RAB9A (0.46) | ALDH1A1KMT2ASMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7300949-B2 | Thiazolopyrazoles and methods of their use | LEXICON PHARMACEUTICALS, INC. (US) | 2007-11-27 | — | — | US | disclosed |
| US-7300949-B2 | Thiazolopyrazoles and methods of their use | LEXICON PHARMACEUTICALS, INC. (US) | 2007-11-27 | — | — | US | disclosed |