Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 12/20 | 0.44 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | OGG1 | O15527 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14361056 | 0.74 | CRHR1 (0.40) | CRHR1RAPGEF4 | |
| SCHEMBL5844341 | 0.73 | CRHR1 (0.59) | CRHR1RAPGEF4 | |
| SCHEMBL14360750 | 0.72 | CRHR1 (0.43) | CRHR1 | |
| SCHEMBL5789078 | 0.71 | CRHR1 (0.50) | CRHR1RAPGEF4 | |
| SCHEMBL5447308 | 0.70 | RAPGEF4 (0.48) | CRHR1RAPGEF4 | |
| SCHEMBL5443606 | 0.70 | RAPGEF4 (0.48) | CRHR1RAPGEF4 | |
| SCHEMBL5844119 | 0.70 | CRHR1 (0.59) | CRHR1RAPGEF4 | |
| SCHEMBL6303533 | 0.69 | CRHR1 (0.48) | CRHR1 | |
| SCHEMBL5843981 | 0.68 | CRHR1 (0.46) | CRHR1 | |
| SCHEMBL5844019 | 0.68 | CRHR1 (0.46) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070270588-A1 | Pyrrolopyrimidine Derivatives | TAISHO PHARMACEUTICAL CO., LTD. | 2007-11-22 | — | — | US | disclosed |
| US-20070270588-A1 | Pyrrolopyrimidine Derivatives | TAISHO PHARMACEUTICAL CO., LTD. | 2007-11-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070270588-A1 | Pyrrolopyrimidine Derivatives | HRH2, ALPI, HRH1 | CRHR1 6/4885RAPGEF4 231/4885CYP19A1 1807/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.