Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX1 | P51575 | 6/20 | 0.67 |
| ▸ | TMPRSS4 | Q9NRS4 | 4/20 | 0.67 |
| ▸ | PLAU | P00749 | 2/20 | 0.63 |
| ▸ | F2 | P00734 | 1/20 | 0.61 |
| ▸ | F10 | P00742 | 1/20 | 0.61 |
| ▸ | PLAT | P00750 | 1/20 | 0.61 |
| ▸ | GRM5 | P41594 | 1/20 | 0.55 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.53 |
| ▸ | RELA | Q04206 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.51 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14363179 | 0.87 | PLAU (0.65) | P2RX1TMPRSS4PLAUF2F10 | |
| SCHEMBL21021862 | 0.86 | PLAU (0.73) | P2RX1TMPRSS4PLAUF2F10 | |
| SCHEMBL330475 | 0.84 | P2RX1 (0.74) | P2RX1TMPRSS4PLAUF2F10 | |
| SCHEMBL23336137 | 0.84 | TMPRSS4 (0.63) | P2RX1TMPRSS4PLAUF2F10 | |
| SCHEMBL6285639 | 0.83 | TMPRSS4 (0.67) | P2RX1TMPRSS4PLAUF2F10 | |
| SCHEMBL14363184 | 0.83 | PLAU (0.69) | P2RX1TMPRSS4PLAUF2F10 | |
| SCHEMBL14363264 | 0.81 | KMT2A (0.60) | P2RX1TMPRSS4PLAUF2F10 | |
| SCHEMBL330257 | 0.81 | P2RX1 (0.77) | P2RX1TMPRSS4PLAUF2F10 | |
| SCHEMBL19040075 | 0.81 | PLAU (0.66) | P2RX1TMPRSS4PLAUF2F10 | |
| SCHEMBL24460276 | 0.81 | P2RX1 (0.77) | P2RX1TMPRSS4PLAUF2F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070276011-A1 | Plasminogen Activator Inhibitor-1 Inhibitor | INSTITUTE OF MEDICINAL MOLECULAR DESIGN. INC. (JP) | 2007-11-29 | — | — | US | disclosed |
| US-20070276011-A1 | Plasminogen Activator Inhibitor-1 Inhibitor | INSTITUTE OF MEDICINAL MOLECULAR DESIGN. INC. (JP) | 2007-11-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070276011-A1 | Plasminogen Activator Inhibitor-1 Inhibitor | SERPINE1, SERPINC1, SERPINB1 | P2RX1 4478/4885TMPRSS4 342/4885PLAU 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.