SCHEMBL14364377

SCHEMBL14364377

C=C[C@@H]1C[C@@]1(C(=O)NS(=O)(=O)c1cccc(OCc2ccccc2)c1)C(C)C

nearest known ligand 0.43

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ POLB P06746 1/20 0.43
▸ BCL2L1 Q07817 4/20 0.42
▸ MCL1 Q07820 3/20 0.42
▸ LMNA P02545 1/20 0.41
▸ PTGES O14684 1/20 0.41
▸ ADAMTS4 O75173 5/20 0.41
▸ MEN1 O00255 1/20 0.41
▸ KMT2A Q03164 1/20 0.41
▸ FAAH O00519 1/20 0.40
▸ CNR2 P34972 1/20 0.40
▸ ADAM17 P78536 2/20 0.40
▸ GHSR Q92847 1/20 0.39
▸ MAOB P27338 1/20 0.39
▸ PPARG P37231 1/20 0.39
▸ PTPN1 P18031 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14278306 0.94 POLB (0.43) POLBBCL2L1MCL1ADAMTS4MEN1
SCHEMBL14278319 0.87 POLB (0.43) POLBBCL2L1MCL1ADAMTS4FAAH
SCHEMBL14277999 0.86 POLB (0.46) POLBBCL2L1MCL1LMNAMEN1
SCHEMBL14301679 0.84 POLB (0.44) POLBBCL2L1MCL1LMNAMEN1
SCHEMBL1015028 0.84 BCL2L1 (0.44) POLBBCL2L1MCL1LMNAMEN1
SCHEMBL1015026 0.84 BCL2L1 (0.44) POLBBCL2L1MCL1LMNAMEN1
SCHEMBL14278301 0.84 ADAMTS4 (0.43) BCL2L1MCL1LMNAADAMTS4KMT2A
SCHEMBL14364344 0.84 POLB (0.43) POLBBCL2L1MCL1LMNAADAMTS4
Hydrochloric Acid SCHEMBL5112794 0.83 BCL2L1 (0.43) POLBBCL2L1MCL1LMNAMEN1
Hydrochloric Acid SCHEMBL5106017 0.83 BCL2L1 (0.43) POLBBCL2L1MCL1LMNAMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070265281-A1 Organic Compounds and Their Uses COTTENS SYLVAIN 2007-11-15 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070265281-A1 Organic Compounds and Their Uses OAT, OTC, AOX1 POLB 419/4885BCL2L1 2218/4885MCL1 1531/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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