Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 3/20 | 0.54 |
| ▸ | CA9 | Q16790 | 3/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | CDK8 | P49336 | 4/20 | 0.51 |
| ▸ | AXL | P30530 | 1/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.51 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.50 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.50 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.50 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.50 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 2/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.43 |
| ▸ | CCND1 | P24385 | 1/20 | 0.43 |
| ▸ | CCNC | P24863 | 1/20 | 0.43 |
| ▸ | CDK7 | P50613 | 1/20 | 0.43 |
| ▸ | CDK9 | P50750 | 1/20 | 0.43 |
| ▸ | CCNH | P51946 | 1/20 | 0.43 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3558164 | 0.77 | CA12 (0.78) | CA12CA9CA2RECQLALDH1A1 | |
| SCHEMBL14365336 | 0.76 | HTR6 (0.58) | CA12CA9CA2CDK8AXL | |
| SCHEMBL30035312 | 0.75 | CA12 (0.53) | CA12CA9CA2RECQLALDH1A1 | |
| SCHEMBL25455031 | 0.71 | CA12 (0.58) | CA12CA9CA2RECQLALDH1A1 | |
| SCHEMBL10226042 | 0.70 | CA12 (0.48) | CA12CA9CA2RECQLALDH1A1 | |
| SCHEMBL25455028 | 0.70 | CA12 (0.56) | CA12CA9CA2RECQLALDH1A1 | |
| SCHEMBL410704 | 0.70 | CDK8 (1.00) | CDK8AXLPIK3CAPIK3CDPIK3CB | |
| SCHEMBL5358792 | 0.69 | CA12 (0.62) | CA12CA9CA2GLO1RECQL | |
| SCHEMBL5349374 | 0.69 | CA12 (0.62) | CA12CA9CA2RECQLALDH1A1 | |
| SCHEMBL425798 | 0.69 | CA12 (0.58) | CA12CA9CA2RECQLALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7291630-B2 | Azaindoles as inhibitors of c-Jun N-terminal kinases | EISAI CO., LTD. (JP) | 2007-11-06 | — | — | US | disclosed |
| US-7291630-B2 | Azaindoles as inhibitors of c-Jun N-terminal kinases | EISAI CO., LTD. (JP) | 2007-11-06 | — | — | US | disclosed |