Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 11/20 | 0.58 |
| ▸ | CA12 | O43570 | 2/20 | 0.52 |
| ▸ | CA9 | Q16790 | 2/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 4/20 | 0.52 |
| ▸ | HTR2A | P28223 | 3/20 | 0.52 |
| ▸ | HTR7 | P34969 | 3/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.49 |
| ▸ | CDK8 | P49336 | 2/20 | 0.49 |
| ▸ | AXL | P30530 | 1/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.48 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.48 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.47 |
| ▸ | FEN1 | P39748 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10125123 | 0.77 | HTR6 (0.51) | HTR6CA12CA9CA1CA2 | |
| SCHEMBL14365337 | 0.76 | CA12 (0.54) | CA12CA9CA2PIK3CACDK8 | |
| SCHEMBL3644542 | 0.75 | HTR6 (1.00) | HTR6CA12CA9CA1CA2 | |
| SCHEMBL724278 | 0.73 | HTR6 (0.61) | HTR6CA12CA9CA1CA2 | |
| SCHEMBL29728507 | 0.73 | HTR6 (0.61) | HTR6CA12CA9CA1CA2 | |
| SCHEMBL31396492 | 0.73 | PTPN11 (0.45) | L3MBTL1PIK3CACDK8FEN1 | |
| SCHEMBL15397145 | 0.72 | PDPK1 (0.84) | HTR6PDPK1 | |
| SCHEMBL2464508 | 0.70 | HTR6 (0.56) | HTR6CA12CA9CA1CA2 | |
| SCHEMBL16990363 | 0.70 | PLK4 (0.48) | HTR6CA12CA9CA1CA2 | |
| SCHEMBL21959033 | 0.69 | HTR6 (0.74) | HTR6CA12CA9CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7291630-B2 | Azaindoles as inhibitors of c-Jun N-terminal kinases | EISAI CO., LTD. (JP) | 2007-11-06 | — | — | US | disclosed |
| US-7291630-B2 | Azaindoles as inhibitors of c-Jun N-terminal kinases | EISAI CO., LTD. (JP) | 2007-11-06 | — | — | US | disclosed |