Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 12/20 | 0.60 |
| ▸ | CA12 | O43570 | 2/20 | 0.53 |
| ▸ | CA9 | Q16790 | 2/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | PLK1 | P53350 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4012211 | 0.89 | HTR6 (0.54) | HTR6CA12CA9CA1CA2 | |
| SCHEMBL4013009 | 0.88 | HTR6 (0.58) | HTR6CA12CA9CA1CA2 | |
| SCHEMBL4014015 | 0.86 | HTR6 (0.66) | HTR6CA12CA9CA1CA2 | |
| SCHEMBL4014386 | 0.80 | HTR6 (0.56) | HTR6CA12CA9CA1CA2 | |
| SCHEMBL4011279 | 0.80 | L3MBTL1 (0.69) | HTR6CA12CA9CA1CA2 | |
| SCHEMBL4016754 | 0.77 | L3MBTL1 (0.54) | HTR6CA12CA9CA1CA2 | |
| SCHEMBL4016525 | 0.77 | HTR6 (0.53) | HTR6CA12CA9CA1CA2 | |
| SCHEMBL3644542 | 0.76 | HTR6 (1.00) | HTR6CA12CA9CA1CA2 | |
| SCHEMBL4013799 | 0.75 | HTR6 (0.59) | HTR6CA12CA9CA1CA2 | |
| SCHEMBL16704081 | 0.74 | HTR6 (0.69) | HTR6LMNASMN1; SMN2PLK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007146838-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-21 | — | — | WO | disclosed |