SCHEMBL4011279

SCHEMBL4011279

Cc1ccc(S(=O)(=O)n2cc(-c3cccc(CC(=O)O)c3)c3ccccc32)cc1

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.69
HTR6 P50406 7/20 0.56
ALOX5 P09917 4/20 0.52
PTGS2 P35354 1/20 0.52
ALK Q9UM73 1/20 0.51
CA12 O43570 1/20 0.50
CA1 P00915 1/20 0.50
CA2 P00918 1/20 0.50
CA9 Q16790 1/20 0.50
KDM4E B2RXH2 1/20 0.49
UBE2N P61088 1/20 0.49
SLC1A3 P43003 1/20 0.49
SLC1A2 P43004 1/20 0.49
SLC1A1 P43005 1/20 0.49
TRIM24 O15164 1/20 0.47
TRIM33 Q9UPN9 1/20 0.47
CFD P00746 1/20 0.47
AGTR1 P30556 1/20 0.45
LMNA P02545 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4014015 0.92 HTR6 (0.66) L3MBTL1HTR6CA12CA1CA2
SCHEMBL4014386 0.90 HTR6 (0.56) L3MBTL1HTR6CA12CA1CA2
SCHEMBL4016754 0.89 L3MBTL1 (0.54) L3MBTL1HTR6CA12CA1CA2
SCHEMBL3933164 0.85 KDM4E (0.48) L3MBTL1HTR6KDM4ELMNA
SCHEMBL4013799 0.83 HTR6 (0.59) L3MBTL1HTR6ALOX5CA12CA1
SCHEMBL4018010 0.80 HTR6 (0.50) L3MBTL1HTR6ALOX5CA12CA1
SCHEMBL4007511 0.80 L3MBTL1 (0.50) L3MBTL1HTR6ALOX5CA12CA1
SCHEMBL14366365 0.80 HTR6 (0.60) L3MBTL1HTR6CA12CA1CA2
SCHEMBL21959033 0.80 HTR6 (0.74) L3MBTL1HTR6CA12CA1CA2
SCHEMBL4013009 0.79 HTR6 (0.58) L3MBTL1HTR6CA12CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2044017-A2 SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS ICOS CORPORATION (US) 2009-04-08 EP claimed
WO-2007146838-A2 SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS ICOS CORPORATION (US) 2007-12-21 WO claimed
EP-2044017-A2 SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS ICOS CORPORATION (US) 2009-04-08 EP disclosed
WO-2007146838-A2 SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS ICOS CORPORATION (US) 2007-12-21 WO disclosed
WO-2007146838-A2 SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS ICOS CORPORATION (US) 2007-12-21 WO disclosed