Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 4/20 | 0.43 |
| ▸ | ANPEP | P15144 | 4/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9969990 | 0.86 | TP53 (0.40) | MMP2ANPEPTP53ALDH1A1 | |
| SCHEMBL12795646 | 0.83 | MMP2 (0.38) | MMP2ANPEPALDH1A1 | |
| SCHEMBL85520 | 0.83 | MMP2 (0.38) | MMP2ANPEPALDH1A1 | |
| SCHEMBL14367126 | 0.79 | MMP2 (0.46) | MMP2ANPEPCA12CA1CA2 | |
| SCHEMBL13661911 | 0.79 | ALDH1A1 (0.46) | MMP2ANPEPALDH1A1 | |
| SCHEMBL16376157 | 0.79 | ALDH1A1 (0.46) | MMP2ANPEPALDH1A1 | |
| SCHEMBL18084393 | 0.79 | ALDH1A1 (0.46) | MMP2ANPEPALDH1A1 | |
| SCHEMBL2610758 | 0.79 | ALDH1A1 (0.46) | MMP2ANPEPALDH1A1 | |
| SCHEMBL2608451 | 0.79 | ALDH1A1 (0.46) | MMP2ANPEPALDH1A1 | |
| SCHEMBL13661915 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7300929-B2 | Mediators of hedgehog signaling pathways, compositions and uses related thereto | CURIS, INC. (US) | 2007-11-27 | — | — | US | disclosed |