Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 5/20 | 0.46 |
| ▸ | ANPEP | P15144 | 4/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5896932 | 0.83 | ATM (0.36) | MMP2ANPEP | |
| SCHEMBL3476452 | 0.81 | MMP2 (0.53) | MMP2ANPEPTP53CA12CA1 | |
| SCHEMBL14077854 | 0.81 | MMP2 (0.42) | MMP2ANPEPALDH1A1CYP3A4MAPT | |
| SCHEMBL13663762 | 0.81 | MMP2 (0.42) | MMP2ANPEPALDH1A1CYP3A4MAPT | |
| SCHEMBL8098379 | 0.80 | MMP2 (0.47) | MMP2ANPEPTP53CA12CA1 | |
| SCHEMBL14367083 | 0.79 | MMP2 (0.43) | MMP2ANPEPTP53CA12CA1 | |
| SCHEMBL21702575 | 0.77 | MMP2 (0.49) | MMP2ANPEPTP53CA12CA1 | |
| SCHEMBL5019084 | 0.77 | CYP2D6 (0.50) | MMP2ANPEPCA1CA2ALDH1A1 | |
| SCHEMBL5691732 | 0.76 | MMP2 (0.48) | MMP2ANPEPALDH1A1CYP3A4 | |
| SCHEMBL14938109 | 0.76 | MMP2 (0.51) | MMP2ANPEPTP53CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7300929-B2 | Mediators of hedgehog signaling pathways, compositions and uses related thereto | CURIS, INC. (US) | 2007-11-27 | — | — | US | disclosed |