Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 7/20 | 0.63 |
| ▸ | LMNA | P02545 | 5/20 | 0.63 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.63 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.63 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.63 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.63 |
| ▸ | HTR1A | P08908 | 2/20 | 0.63 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.63 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.63 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.63 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.63 |
| ▸ | DRD2 | P14416 | 2/20 | 0.63 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.63 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1137893 | 0.81 | OPRD1 (0.68) | OPRD1LMNAHIF1AOPRM1CYP3A4 | |
| SCHEMBL9837345 | 0.81 | OPRD1 (0.68) | OPRD1LMNAHIF1AOPRM1CYP3A4 | |
| SCHEMBL1137896 | 0.81 | OPRD1 (0.68) | OPRD1LMNAHIF1AOPRM1CYP3A4 | |
| SCHEMBL9837343 | 0.81 | OPRD1 (0.68) | OPRD1LMNAHIF1AOPRM1CYP3A4 | |
| SCHEMBL1138084 | 0.80 | NPC1 (0.60) | OPRD1LMNAHIF1AOPRM1CYP3A4 | |
| SCHEMBL1138082 | 0.80 | NPC1 (0.60) | OPRD1LMNAHIF1AOPRM1CYP3A4 | |
| SCHEMBL6554369 | 0.80 | OPRD1 (0.56) | OPRD1LMNAHIF1AOPRM1CYP3A4 | |
| Hydrochloric Acid SCHEMBL1138342 | 0.79 | HRH1 (0.58) | OPRD1LMNAHIF1AOPRM1CYP3A4 | |
| Hydrochloric Acid SCHEMBL1138343 | 0.79 | HRH1 (0.58) | OPRD1LMNAHIF1AOPRM1CYP3A4 | |
| SCHEMBL14367175 | 0.78 | OPRD1 (0.54) | OPRD1LMNAHIF1AOPRM1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7297697-B2 | with alkenyl moiety substituted at the 1-position of the piperazine unit; useful in the treatment of histamine mediated diseases | SUN PHARMACEUTICAL INDUSTRIES LIMITED (IN) | 2007-11-20 | — | — | US | disclosed |