Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 7/20 | 0.68 |
| ▸ | LMNA | P02545 | 6/20 | 0.68 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.68 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.68 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.68 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.68 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.68 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.68 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.68 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.68 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.68 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.68 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.68 |
| ▸ | DRD1 | P21728 | 3/20 | 0.68 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.68 |
| ▸ | HTR2A | P28223 | 3/20 | 0.68 |
| ▸ | HRH1 | P35367 | 3/20 | 0.68 |
| ▸ | DRD3 | P35462 | 3/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9837345 | 1.00 | OPRD1 (0.68) | OPRD1LMNAOPRM1HIF1ACYP2D6 | |
| SCHEMBL1137893 | 0.84 | OPRD1 (0.68) | OPRD1LMNAOPRM1HIF1ACYP2D6 | |
| SCHEMBL1137896 | 0.84 | OPRD1 (0.68) | OPRD1LMNAOPRM1HIF1ACYP2D6 | |
| Cinnarizine SCHEMBL16225873 | 0.81 | LMNA (1.00) | OPRD1LMNAOPRM1HIF1ACYP2D6 | |
| Cinnarizine SCHEMBL44958 | 0.81 | LMNA (1.00) | OPRD1LMNAOPRM1HIF1ACYP2D6 | |
| Cinnarizine SCHEMBL44957 | 0.81 | LMNA (1.00) | OPRD1LMNAOPRM1HIF1ACYP2D6 | |
| Cinnarizine SCHEMBL1815115 | 0.81 | LMNA (1.00) | OPRD1LMNAOPRM1HIF1ACYP2D6 | |
| SCHEMBL14367172 | 0.81 | OPRD1 (0.63) | OPRD1LMNAOPRM1HIF1ACYP2D6 | |
| Cinnarizine SCHEMBL3731524 | 0.80 | LMNA (0.97) | OPRD1LMNAOPRM1HIF1ACYP2D6 | |
| Cinnarizine SCHEMBL10936878 | 0.80 | LMNA (0.97) | OPRD1LMNAOPRM1HIF1ACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0210782-B1 | PYRIDINE COMPOUNDS, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | Dainippon Pharmaceutical Co., Ltd. (JP) | 1991-04-17 | — | — | EP | disclosed |
| US-4778796-A | ω-(3-pyridyl)alkenamide derivatives and anti-allergenic pharmaceutical compositions containing same | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1988-10-18 | — | — | US | disclosed |
| EP-0210782-A2 | Pyridine compounds, process for the preparation thereof and pharmaceutical composition containing the same | Dainippon Pharmaceutical Co., Ltd. (JP) | 1987-02-04 | — | — | EP | disclosed |