Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 3/20 | 0.60 |
| ▸ | MYC | P01106 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | TYMS | P04818 | 1/20 | 0.37 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | G6PD | P11413 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | CASP6 | P55212 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29885350 | 1.00 | TOP2A (0.60) | TOP2AMYCIDO1MAOAMAOB | |
| SCHEMBL2955256 | 0.86 | MYC (0.49) | TOP2AMYCIDO1MAOAMAOB | |
| SCHEMBL14367754 | 0.85 | TOP2A (0.75) | TOP2AIDO1MAOAMAOBKDM4E | |
| SCHEMBL3401507 | 0.83 | TOP2A (0.58) | TOP2AMYCIDO1MAOAMAOB | |
| SCHEMBL2959863 | 0.82 | TOP2A (0.70) | TOP2AIDO1MAOAMAOBKDM4E | |
| SCHEMBL10731139 | 0.78 | TOP2A (0.55) | TOP2AMYCAGPAT2KDM4EALDH1A1 | |
| SCHEMBL12807868 | 0.77 | TOP2A (0.72) | TOP2AAGPAT2KDM4EALDH1A1HSD17B10 | |
| SCHEMBL11979724 | 0.75 | TOP2A (1.00) | TOP2AAGPAT2KDM4EALDH1A1HPGD | |
| SCHEMBL29354263 | 0.75 | TOP2A (1.00) | TOP2AAGPAT2KDM4EALDH1A1HPGD | |
| SCHEMBL17929359 | 0.75 | TOP2A (0.78) | TOP2AAGPAT2KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7294643-B2 | UK-1 analogues: methods of preparation and use | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2007-11-13 | — | — | US | disclosed |
| US-7294643-B2 | UK-1 analogues: methods of preparation and use | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2007-11-13 | — | — | US | disclosed |