Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK5 | Q8IW41 | 4/20 | 0.39 |
| ▸ | SYK | P43405 | 4/20 | 0.32 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 2/20 | 0.31 |
| ▸ | TNF | P01375 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.31 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.31 |
| ▸ | BTK | Q06187 | 3/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.30 |
| ▸ | CD38 | P28907 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2219824 | 0.85 | RET (0.43) | MAPKAPK5RETBTKMAPTMAPK1 | |
| SCHEMBL3797299 | 0.76 | POLB (0.42) | RETBTKMAPTMAPK1EGFR | |
| SCHEMBL13918176 | 0.74 | POLB (0.40) | RETBTKMAPTMAPK1EGFR | |
| SCHEMBL3802954 | 0.74 | ALDH1A1 (0.35) | SYKPTK6AURKBRETBTK | |
| SCHEMBL10169559 | 0.74 | MAPKAPK5 (0.54) | MAPKAPK5SYKRETMAPT | |
| SCHEMBL13918219 | 0.73 | BTK (0.35) | MAPKAPK5PTK6AURKBBTKMAPT | |
| SCHEMBL1477791 | 0.72 | ROCK2 (0.50) | MAPKAPK5PTK6AURKB | |
| SCHEMBL1674336 | 0.72 | MAPKAPK5 (0.52) | MAPKAPK5SYKPTK6AURKBRET | |
| SCHEMBL1476816 | 0.70 | MAPKAPK5 (0.46) | MAPKAPK5PTK6AURKB | |
| SCHEMBL12515799 | 0.69 | MAPKAPK5 (0.51) | MAPKAPK5SYKCD38 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007138072-A2 | TRIAZOLOPYRAZINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS N.V. (BE) | 2007-12-06 | — | — | WO | disclosed |