Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | RET | P07949 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | GAK | O14976 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3802954 | 0.91 | ALDH1A1 (0.35) | POLBRETALDH1A1HPGDMAPT | |
| SCHEMBL2219824 | 0.90 | RET (0.43) | POLBRETALDH1A1MEN1KMT2A | |
| SCHEMBL13918176 | 0.87 | POLB (0.40) | POLBRETALDH1A1MEN1KMT2A | |
| SCHEMBL1477791 | 0.84 | ROCK2 (0.50) | POLBALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL13918219 | 0.79 | BTK (0.35) | POLBALDH1A1HPGDMAPTKDM4E | |
| SCHEMBL10169559 | 0.78 | MAPKAPK5 (0.54) | POLBRETALDH1A1MEN1KMT2A | |
| SCHEMBL3794612 | 0.76 | RAB9A (0.40) | POLBALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL14368591 | 0.76 | MAPKAPK5 (0.39) | RETMAPTMAPK1EGFRBTK | |
| SCHEMBL1476816 | 0.75 | MAPKAPK5 (0.46) | — | |
| SCHEMBL3798752 | 0.73 | MAPKAPK5 (0.61) | KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029602-B1 | TRIAZOLOPYRAZINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2010-04-21 | — | — | EP | claimed |