Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Betahistine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 known ✓ | Q9Y5N1 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.83 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.83 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.65 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.65 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.43 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Betahistine SCHEMBL2594682 | 0.94 | HRH3 (0.75) | LMNATDP1HRH3ALDH1A1ALOX15 | |
| Betahistine SCHEMBL30679317 | 0.91 | LMNA (1.00) | LMNATDP1HRH3ALDH1A1ALOX15 | |
| Betahistine SCHEMBL194604 | 0.91 | LMNA (1.00) | LMNATDP1HRH3ALDH1A1ALOX15 | |
| Betahistine SCHEMBL195108 | 0.91 | LMNA (1.00) | LMNATDP1HRH3ALDH1A1ALOX15 | |
| Betahistine SCHEMBL9319899 | 0.89 | HRH3 (0.71) | LMNATDP1HRH3ALDH1A1ALOX15 | |
| Betahistine SCHEMBL9844622 | 0.88 | LMNA (0.94) | LMNATDP1HRH3ALDH1A1ALOX15 | |
| Betahistine SCHEMBL20421884 | 0.88 | LMNA (0.94) | LMNATDP1HRH3ALDH1A1ALOX15 | |
| Betahistine SCHEMBL22129683 | 0.87 | LMNA (0.91) | LMNATDP1HRH3ALDH1A1ALOX15 | |
| Betahistine SCHEMBL9321873 | 0.87 | HRH3 (0.77) | LMNATDP1HRH3ALDH1A1ALOX15 | |
| Betahistine SCHEMBL20421888 | 0.85 | HRH3 (0.80) | LMNATDP1HRH3ALDH1A1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024149635-A1 | BRANCHED AMINES AS ADDITIVES FOR GASOLINE FUELS | BASF SE (DE) | 2024-07-18 | — | — | WO | claimed |
| EP-4284902-A1 | BRANCHED PRIMARY ALKYL AMINES AS ADDITIVES FOR GASOLINE FUELS | BASF SE (DE) | 2023-12-06 | — | — | EP | claimed |
| EP-4263766-A2 | MIXTURES FOR IMPROVING THE STABILITY OF ADDITIVE PACKAGES | BASF SE (DE) | 2023-10-25 | — | — | EP | claimed |
| WO-2022161803-A1 | BRANCHED PRIMARY ALKYL AMINES AS ADDITIVES FOR GASOLINE FUELS | BASF SE (DE) | 2022-08-04 | — | — | WO | claimed |
| WO-2022128569-A2 | NEW MIXTURES FOR IMPROVING THE STABILITY OF ADDITIVE PACKAGES | BASF SE (DE) | 2022-06-23 | — | — | WO | claimed |
| EP-2470606-A1 | HIGH STRENGTH CARBO SUBSTANCES | Chr. Hansen A/S (DK) | 2012-07-04 | — | — | EP | claimed |
| WO-2011023673-A1 | HIGH STRENGTH CARBO SUBSTANCES | CHR. HANSEN A/S (DK) | 2011-03-03 | — | — | WO | claimed |
| EP-2176357-A2 | A COLOURING COMPOSITION COMPRISING STARCH DERIVATIVES AS A HYDROCOLLOID | Chr. Hansen A/S (DK) | 2010-04-21 | — | — | EP | disclosed |
| WO-2009007273-A2 | A COLOURING COMPOSITION COMPRISING STARCH DERIVATIVES AS A HYDROCOLLOID | CHR. HANSEN A/S (DK) | 2009-01-15 | — | — | WO | disclosed |
| EP-1709145-A1 | SANITIZING AND CLEANING COMPOSITION AND ITS USE FOR SANITIZING AND/OR CLEANING HARD SURFACES | JohnsonDiversey, Inc. (US) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005073359-A1 | SANITIZING AND CLEANING COMPOSITION AND ITS USE FOR SANITIZING AND/OR CLEANING HARD SURFACES | JOHNSONDIVERSEY, INC. (US) | 2005-08-11 | — | — | WO | disclosed |