Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Betahistine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 known ✓ | Q9Y5N1 | 1/20 | 0.73 |
| ▸ | LMNA | P02545 | 2/20 | 0.91 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.91 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.71 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.71 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.71 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | APP | P05067 | 2/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.43 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Betahistine SCHEMBL194604 | 0.95 | LMNA (1.00) | LMNATDP1HRH3ALDH1A1TAAR1 | |
| Betahistine SCHEMBL30679317 | 0.95 | LMNA (1.00) | LMNATDP1HRH3ALDH1A1TAAR1 | |
| Betahistine SCHEMBL195108 | 0.95 | LMNA (1.00) | LMNATDP1HRH3ALDH1A1TAAR1 | |
| Betahistine SCHEMBL9844622 | 0.92 | LMNA (0.94) | LMNATDP1HRH3ALDH1A1TAAR1 | |
| Betahistine SCHEMBL20421884 | 0.92 | LMNA (0.94) | LMNATDP1HRH3ALDH1A1TAAR1 | |
| Betahistine SCHEMBL1437009 | 0.87 | LMNA (0.83) | LMNATDP1HRH3ALDH1A1TAAR1 | |
| Betahistine SCHEMBL125582 | 0.85 | HRH3 (1.00) | LMNATDP1HRH3ALDH1A1TAAR1 | |
| Betahistine SCHEMBL28346535 | 0.85 | HRH3 (1.00) | LMNATDP1HRH3ALDH1A1TAAR1 | |
| Betahistine SCHEMBL29354603 | 0.85 | HRH3 (1.00) | LMNATDP1HRH3ALDH1A1TAAR1 | |
| Betahistine SCHEMBL10770127 | 0.85 | LMNA (0.79) | LMNATDP1HRH3ALDH1A1TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021241049-A1 | COSMETIC PREPARATAION | 信越化学工業株式会社 | 2021-12-02 | — | — | WO | disclosed |
| WO-2021215084-A1 | MICROEMULSION COMPOSITION AND COSMETIC CONTAINING SAME | 信越化学工業株式会社 (JP) | 2021-10-28 | — | — | WO | disclosed |
| WO-2021075182-A1 | WATER-DISPERSED EMULSION COMPOSITION, METHOD FOR PRODUCING SAME, EMULSION ADDITION-CURED COMPOSITION, AND COSMETIC PREPARATION | 信越化学工業株式会社 | 2021-04-22 | — | — | WO | disclosed |
| WO-2020129461-A1 | MICROEMULSION COMPOSITION, CURED PRODUCT THEREOF, AND COSMETIC MATERIAL CONTAINING SAME | 信越化学工業株式会社 | 2020-06-25 | — | — | WO | disclosed |