Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Betahistine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 known ✓ | Q9Y5N1 | 1/20 | 0.80 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.77 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.77 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.77 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | APP | P05067 | 2/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.46 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Betahistine SCHEMBL195108 | 1.00 | LMNA (1.00) | LMNATDP1HRH3ALDH1A1TAAR1 | |
| Betahistine SCHEMBL30679317 | 1.00 | LMNA (1.00) | LMNATDP1HRH3ALDH1A1TAAR1 | |
| Betahistine SCHEMBL9844622 | 0.97 | LMNA (0.94) | LMNATDP1HRH3ALDH1A1TAAR1 | |
| Betahistine SCHEMBL20421884 | 0.97 | LMNA (0.94) | LMNATDP1HRH3ALDH1A1TAAR1 | |
| Betahistine SCHEMBL22129683 | 0.95 | LMNA (0.91) | LMNATDP1HRH3ALDH1A1TAAR1 | |
| Betahistine SCHEMBL1437009 | 0.91 | LMNA (0.83) | LMNATDP1HRH3ALDH1A1TAAR1 | |
| Betahistine SCHEMBL125582 | 0.89 | HRH3 (1.00) | LMNATDP1HRH3ALDH1A1TAAR1 | |
| Betahistine SCHEMBL28346535 | 0.89 | HRH3 (1.00) | LMNATDP1HRH3ALDH1A1TAAR1 | |
| Betahistine SCHEMBL29354603 | 0.89 | HRH3 (1.00) | LMNATDP1HRH3ALDH1A1TAAR1 | |
| Betahistine SCHEMBL10770127 | 0.89 | LMNA (0.79) | LMNATDP1HRH3ALDH1A1TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1435 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4673146-A2 | METHODS FOR TREATING OBSESSIVE COMPULSIVE RELATED DISORDERS, TIC DISORDERS AND GLUTAMATE EXCITOTOXICITY RELATED DISORDERS | Biohaven Therapeutics Ltd. (VG) | 2026-01-07 | — | — | EP | claimed |
| CN-119632939-A | Betahistine mesylate tablet and preparation method thereof | 珠海润都制药股份有限公司 | 2025-03-18 | — | — | CN | claimed |
| CN-119194883-A | Pure physical pulping process for coniferous forest and tencel | 深圳镓电科技有限公司 | 2024-12-27 | — | — | CN | claimed |
| CN-117310034-B | Detection method of genotoxic impurities in betahistine mesylate | 石家庄四药有限公司 | 2024-12-06 | — | — | CN | claimed |
| WO-2024182465-A2 | METHODS FOR TREATING OBSESSIVE COMPULSIVE RELATED DISORDERS, TIC DISORDERS AND GLUTAMATE EXCITOTOXICITY RELATED DISORDERS | ALCO THERAPEUTICS, LLC (US) | 2024-09-06 | — | — | WO | claimed |
| CN-118530167-A | Synthesis method of betahistine and mesylate thereof and product | 北京隆熙生物科技有限公司 | 2024-08-23 | — | — | CN | claimed |
| CN-118436591-A | External preparation of betahistine and application thereof | 山东序列生物科技有限公司 | 2024-08-06 | — | — | CN | claimed |
| CN-118356397-A | Intranasal compositions comprising betahistine | 欧托拉农股份有限公司 | 2024-07-19 | — | — | CN | claimed |
| WO-2024149635-A1 | BRANCHED AMINES AS ADDITIVES FOR GASOLINE FUELS | BASF SE (DE) | 2024-07-18 | — | — | WO | claimed |
| CN-118330109-A | High performance liquid phase detection method for betahistine or mesylate thereof | 仙琚(嘉兴)医药科技有限公司 | 2024-07-12 | — | — | CN | claimed |
| WO-2004096816-A1 | DICOPPER (I) OXALATE COMPLEXES AS PRECURSOR FOR METALLIC COPPER DEPOSITION | BASF AKTIENGESELLSCHAFT (DE) | 2004-11-11 | — | — | WO | claimed |
| WO-2004000850-A1 | DICOPPER(I)OXALATE COMPLEXES FOR USE AS PRECURSOR SUBSTANCES IN METALLIC COPPER DEPOSITION | MERCK PATENT GMBH (DE) | 2003-12-31 | — | — | WO | claimed |
| CN-1418091-A | Pharmaceutical preparations | AWD PHARMA GMBH & CO KG (DE) | 2003-05-14 | — | — | CN | claimed |
| EP-0729748-B1 | PROCESS FOR PRODUCING STABLE MEDICINAL COMPOSITION | NIPPON SHINYAKU CO LTD (JP) | 2003-02-26 | — | — | EP | claimed |
| WO-2001037652-A2 | CARBAMOYL TRIAZOLINONE-BASED HERBICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 2001-05-31 | — | — | WO | claimed |
| US-5811547-A | Method for inducing crystalline state transition in medicinal substance | NIPPON SHINYAJU CO., LTD. (JP) | 1998-09-22 | — | — | US | claimed |
| US-5700410-A | Method of manufacturing wax matrices | NIPPON SHINYAKU CO., LTD. (JP) | 1997-12-23 | — | — | US | claimed |
| US-5688510-A | POWDER, MACROLOLECULAR ADDITIVE | NIPPON SHINYAKU CO. LTD. (JP) | 1997-11-18 | — | — | US | claimed |
| EP-0580860-B1 | METHOD OF MANUFACTURING SOLID DISPERSION | NIPPON SHINYAKU CO LTD (JP) | 1997-10-22 | — | — | EP | claimed |
| EP-0729748-A1 | PROCESS FOR PRODUCING STABLE MEDICINAL COMPOSITION, AND PHARMACEUTICAL PREPARATION | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1996-09-04 | — | — | EP | claimed |