Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 8/20 | 0.49 |
| ▸ | GSK3B | P49841 | 2/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13986980 | 0.88 | SNCA (0.60) | SNCAGSK3BPTGS1PTGS2HPGD | |
| SCHEMBL13986969 | 0.88 | GAA (0.57) | SNCAGSK3BPTGS1PTGS2GAA | |
| SCHEMBL13986973 | 0.86 | SIRT1 (0.56) | GSK3BPTGS1PTGS2SMN1; SMN2SIRT1 | |
| SCHEMBL13987008 | 0.85 | KMT2A (0.59) | PTGS1PTGS2TRPV1HPGD | |
| SCHEMBL13986972 | 0.80 | MTNR1A (0.56) | GSK3BPTGS1PTGS2TRPV1GAA | |
| SCHEMBL13986963 | 0.77 | GSK3B (0.56) | GSK3BGAAPARP1SMN1; SMN2MAPT | |
| SCHEMBL13986986 | 0.76 | GSK3B (0.66) | GSK3BGAAPARP1SMN1; SMN2MAPT | |
| SCHEMBL13986979 | 0.76 | MAPT (0.65) | GSK3BGAAMAPT | |
| SCHEMBL13986961 | 0.76 | GSK3B (0.55) | GSK3BGAAPARP1SMN1; SMN2MAPT | |
| SCHEMBL13986976 | 0.75 | P2RX7 (0.63) | GSK3BGAAHPGDPARP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7309701-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-12-18 | — | — | US | disclosed |