Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.48 |
| ▸ | NPC1 | O15118 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14375940 | 0.83 | SMN1; SMN2 (0.47) | RAB9ANPC1SMN1; SMN2HPGDPOLB | |
| SCHEMBL14375920 | 0.79 | HPGD (0.41) | RAB9ANPC1SMN1; SMN2HPGDPOLB | |
| SCHEMBL14375942 | 0.78 | SMN1; SMN2 (0.43) | RAB9ANPC1ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL6745420 | 0.74 | ERCC1 (0.54) | NPC1ALDH1A1SMN1; SMN2HPGDLMNA | |
| SCHEMBL14375914 | 0.73 | CA12 (0.40) | NPC1SMN1; SMN2HPGDPOLBLMNA | |
| SCHEMBL10386822 | 0.71 | KDM4E (0.57) | ALDH1A1SMN1; SMN2HPGDPOLBLMNA | |
| SCHEMBL14375950 | 0.71 | KDM4E (0.42) | RAB9ANPC1ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL14375925 | 0.69 | NTRK1 (0.36) | RAB9ANPC1SMN1; SMN2HPGDPOLB | |
| SCHEMBL14347625 | 0.68 | KMT2A (0.43) | RAB9ANPC1ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL14374465 | 0.68 | KMT2A (0.43) | RAB9ANPC1ALDH1A1SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7279576-B2 | Anti-cancer medicaments | DECIPHERA PHARMACEUTICALS, LLC (US) | 2007-10-09 | — | — | US | disclosed |
| US-7279576-B2 | Anti-cancer medicaments | DECIPHERA PHARMACEUTICALS, LLC (US) | 2007-10-09 | — | — | US | disclosed |