Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | CALCRL | Q16602 | 5/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | BLM | P54132 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | PARG | Q86W56 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14375915 | 0.79 | RAB9A (0.48) | HPGDSMN1; SMN2POLBL3MBTL1LMNA | |
| SCHEMBL14375942 | 0.76 | SMN1; SMN2 (0.43) | HPGDSMN1; SMN2POLBL3MBTL1LMNA | |
| SCHEMBL14375914 | 0.75 | CA12 (0.40) | HPGDSMN1; SMN2POLBL3MBTL1LMNA | |
| SCHEMBL14375940 | 0.72 | SMN1; SMN2 (0.47) | HPGDSMN1; SMN2POLBL3MBTL1LMNA | |
| SCHEMBL6745420 | 0.72 | ERCC1 (0.54) | HPGDSMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL14375905 | 0.71 | ABL1 (0.41) | LMNACYP3A4CA12CA9 | |
| SCHEMBL14375907 | 0.70 | NPC1 (0.48) | HPGDSMN1; SMN2POLBMAPTMEN1 | |
| SCHEMBL10386822 | 0.69 | KDM4E (0.57) | HPGDSMN1; SMN2POLBLMNAMAPT | |
| SCHEMBL14375950 | 0.69 | KDM4E (0.42) | HPGDSMN1; SMN2POLBL3MBTL1LMNA | |
| SCHEMBL13296550 | 0.67 | MAPK14 (0.65) | MAPTCYP2D6NTRK1NTRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7279576-B2 | Anti-cancer medicaments | DECIPHERA PHARMACEUTICALS, LLC (US) | 2007-10-09 | — | — | US | disclosed |