Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | BLM | P54132 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.38 |
| ▸ | NTRK2 | Q16620 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14375915 | 0.78 | RAB9A (0.48) | SMN1; SMN2HPGDPOLBL3MBTL1LMNA | |
| SCHEMBL14375940 | 0.78 | SMN1; SMN2 (0.47) | SMN1; SMN2HPGDPOLBL3MBTL1LMNA | |
| SCHEMBL14375920 | 0.76 | HPGD (0.41) | SMN1; SMN2HPGDPOLBL3MBTL1LMNA | |
| SCHEMBL6745420 | 0.75 | ERCC1 (0.54) | SMN1; SMN2HPGDLMNAMEN1KMT2A | |
| SCHEMBL10386822 | 0.72 | KDM4E (0.57) | SMN1; SMN2HPGDPOLBLMNAMAPT | |
| SCHEMBL14375950 | 0.72 | KDM4E (0.42) | SMN1; SMN2HPGDPOLBL3MBTL1LMNA | |
| SCHEMBL14375894 | 0.72 | ABL1 (0.44) | LMNAMAPTMEN1KMT2ACYP3A4 | |
| SCHEMBL14375914 | 0.71 | CA12 (0.40) | SMN1; SMN2HPGDPOLBL3MBTL1LMNA | |
| SCHEMBL14374465 | 0.69 | KMT2A (0.43) | SMN1; SMN2HPGDPOLBL3MBTL1LMNA | |
| SCHEMBL14347625 | 0.69 | KMT2A (0.43) | SMN1; SMN2HPGDPOLBL3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7279576-B2 | Anti-cancer medicaments | DECIPHERA PHARMACEUTICALS, LLC (US) | 2007-10-09 | — | — | US | disclosed |
| US-7279576-B2 | Anti-cancer medicaments | DECIPHERA PHARMACEUTICALS, LLC (US) | 2007-10-09 | — | — | US | disclosed |