Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | POLQ | O75417 | 2/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14200369 | 0.80 | ALDH1A1 (0.57) | NPSR1KMT2ARAB9ANPC1ALDH1A1 | |
| SCHEMBL3594791 | 0.78 | GSK3B (0.39) | NPSR1KMT2ARAB9AMEN1 | |
| SCHEMBL10224337 | 0.72 | CYP3A4 (0.55) | NPSR1KMT2ARAB9APOLBCYP3A4 | |
| SCHEMBL17591691 | 0.69 | CYP3A4 (0.46) | ALDH1A1HTTHDAC6HDAC1CYP3A4 | |
| SCHEMBL15638808 | 0.69 | AGTR1 (0.42) | KMT2ARAB9APOLBSMN1; SMN2POLQ | |
| SCHEMBL4120574 | 0.66 | KMT2A (0.56) | NPSR1KMT2ARAB9ANPC1ALDH1A1 | |
| SCHEMBL8331576 | 0.66 | ALDH1A1 (0.61) | KMT2AALDH1A1HTTCYP3A4CYP2C9 | |
| SCHEMBL28689412 | 0.65 | PTPN1 (0.38) | KMT2ARAB9ANPC1ALDH1A1HTT | |
| SCHEMBL15085775 | 0.65 | ALDH1A1 (0.65) | NPSR1KMT2AALDH1A1HTTCYP3A4 | |
| SCHEMBL5418382 | 0.65 | PAX8 (0.38) | NPSR1KMT2AHDAC6HDAC1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007125351-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF AMYLOID-RELATED DISEASES | SENEXIS LIMITED (GB) | 2007-11-08 | — | — | WO | disclosed |