Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | FNTA | P49354 | 1/20 | 0.39 |
| ▸ | FNTB | P49356 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.39 |
| ▸ | HPGD | P15428 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | GMNN | O75496 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | BLM | P54132 | 2/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4828397 | 0.83 | LMNA (0.44) | LMNANPC1FNTAFNTBPTPN1 | |
| SCHEMBL4828442 | 0.82 | NPC1 (0.59) | LMNANPC1FNTAFNTBPTPN1 | |
| SCHEMBL4835943 | 0.71 | LMNA (0.51) | LMNANPC1PTPN1ALDH1A1HPGD | |
| SCHEMBL4831696 | 0.70 | HPGD (0.52) | LMNANPC1ALDH1A1HPGDKDM4E | |
| SCHEMBL4831567 | 0.69 | LMNA (0.46) | LMNANPC1ALDH1A1HPGDHSD17B10 | |
| SCHEMBL1301580 | 0.67 | SMN1; SMN2 (0.54) | LMNANPC1ALDH1A1HPGDKDM4E | |
| SCHEMBL4837029 | 0.67 | KDM4E (0.61) | NPC1PTPN1ALDH1A1HPGDKDM4E | |
| SCHEMBL27552877 | 0.67 | ALDH1A1 (0.50) | LMNAALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL4828432 | 0.67 | LMNA (0.47) | LMNAALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL14714619 | 0.67 | MTNR1A (0.47) | LMNAKDM4EMTNR1AMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1474140-B1 | 2-OXAZOLAMINES AND THEIR USE AS 5-HT2B RECEPTOR ANTAGONISTS | ASTERAND UK LTD (GB) | 2007-11-21 | — | — | EP | disclosed |