Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 5/20 | 0.56 |
| ▸ | PPM1B | O75688 | 5/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | GMNN | O75496 | 3/20 | 0.56 |
| ▸ | TFPI2 | P48307 | 3/20 | 0.56 |
| ▸ | PMP22 | Q01453 | 3/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.56 |
| ▸ | THPO | P40225 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | PPP1CC | P36873 | 2/20 | 0.56 |
| ▸ | PPP5C | P53041 | 2/20 | 0.56 |
| ▸ | PPP1CA | P62136 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17773447 | 1.00 | TP53 (0.56) | TP53PPM1BLMNASMN1; SMN2KDM4E | |
| SCHEMBL13311452 | 1.00 | TP53 (0.56) | TP53PPM1BLMNASMN1; SMN2KDM4E | |
| SCHEMBL2548229 | 1.00 | TP53 (0.56) | TP53PPM1BLMNASMN1; SMN2KDM4E | |
| Demethyl-Cantharidin SCHEMBL19318920 | 0.72 | TP53 (1.00) | TP53PPM1BLMNASMN1; SMN2KDM4E | |
| Demethyl-Cantharidin SCHEMBL9675442 | 0.72 | TP53 (1.00) | TP53PPM1BLMNASMN1; SMN2KDM4E | |
| Demethyl-Cantharidin SCHEMBL3195020 | 0.72 | TP53 (1.00) | TP53PPM1BLMNASMN1; SMN2KDM4E | |
| SCHEMBL2120400 | 0.72 | PPM1B (0.56) | TP53PPM1BLMNASMN1; SMN2KDM4E | |
| Demethyl-Cantharidin SCHEMBL177729 | 0.72 | TP53 (1.00) | TP53PPM1BLMNASMN1; SMN2KDM4E | |
| SCHEMBL13556829 | 0.72 | PPM1B (0.56) | TP53PPM1BLMNASMN1; SMN2KDM4E | |
| SCHEMBL407914 | 0.72 | PPM1B (0.56) | TP53PPM1BLMNASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1854798-A2 | Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function | Bristol-Myers Squibb Company (US) | 2007-11-14 | — | — | EP | disclosed |