Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | GAA | P10253 | 4/20 | 0.51 |
| ▸ | HPGDS | O60760 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 2/20 | 0.48 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.41 |
| ▸ | TUBB | P07437 | 1/20 | 0.41 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.41 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.41 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1436956 | 0.90 | PIP4K2A (0.44) | NPC1RAB9AALDH1A1MAPTGAA | |
| SCHEMBL10002437 | 0.76 | MDM2 (0.48) | ALDH1A1MAPTKMT2ANPSR1HPGD | |
| SCHEMBL9893767 | 0.76 | MDM2 (0.47) | ALDH1A1MAPTKMT2ANPSR1HPGD | |
| Lithium SCHEMBL9893769 | 0.76 | MDM2 (0.47) | ALDH1A1MAPTKMT2ANPSR1HPGD | |
| Lithium Ion SCHEMBL9893768 | 0.74 | TUBB4A (0.41) | ALDH1A1MAPTKMT2ANPSR1TUBB4A | |
| SCHEMBL5099550 | 0.73 | PDE4D (0.56) | NPC1ALDH1A1MAPTFYNPDE4B | |
| SCHEMBL8765024 | 0.72 | RAB9A (0.69) | NPC1RAB9AALDH1A1MAPTGAA | |
| SCHEMBL3759371 | 0.72 | PTGDR2 (0.57) | ALDH1A1KMT2AMEN1NPSR1HPGD | |
| SCHEMBL29634149 | 0.72 | PTGDR2 (0.57) | ALDH1A1KMT2AMEN1NPSR1HPGD | |
| SCHEMBL28301005 | 0.71 | NPC1 (0.47) | NPC1RAB9AALDH1A1MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011023677-A1 | TETRA-SUBSTITUTED HETEROARYL COMPOUNDS AND THEIR USE AS MDM2 AND/OR MDM4 MODULATORS | NOVARTIS AG (CH) | 2011-03-03 | — | — | WO | disclosed |