Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | USP2 | O75604 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 5/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | CA7 | P43166 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13815374 | 0.92 | LMNA (0.70) | HSD17B10LMNAUSP2ALDH1A1TDP1 | |
| SCHEMBL13823307 | 0.84 | HSD17B10 (0.73) | HSD17B10LMNAUSP2ALDH1A1TDP1 | |
| Quinethazone SCHEMBL301310 | 0.79 | LMNA (1.00) | HSD17B10LMNAUSP2ALDH1A1TDP1 | |
| Quinethazone SCHEMBL380450 | 0.79 | LMNA (1.00) | HSD17B10LMNAUSP2ALDH1A1TDP1 | |
| SCHEMBL11929250 | 0.72 | TNKS2 (0.46) | HSD17B10LMNAUSP2ALDH1A1KDM4E | |
| Mebutizide SCHEMBL13725122 | 0.69 | LMNA (0.64) | HSD17B10LMNAUSP2ALDH1A1TDP1 | |
| SCHEMBL11759388 | 0.66 | ATM (0.53) | HSD17B10LMNAALDH1A1TDP1NR3C1 | |
| Metolazone SCHEMBL1568915 | 0.64 | ALDH1A1 (0.81) | HSD17B10LMNAUSP2ALDH1A1TDP1 | |
| SCHEMBL13815373 | 0.60 | CHRM1 (0.71) | HSD17B10LMNAUSP2ALDH1A1TDP1 | |
| SCHEMBL4906719 | 0.59 | CA12 (0.52) | ALDH1A1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7282519-B2 | Nitrosated and nitrosylated diuretic compounds, compositions and methods of use | NITROMED, INC. (US) | 2007-10-16 | — | — | US | disclosed |