Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 5/20 | 0.53 |
| ▸ | ABL1 | P00519 | 2/20 | 0.50 |
| ▸ | BCR | P11274 | 2/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.50 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.50 |
| ▸ | GSK3B | P49841 | 2/20 | 0.50 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.47 |
| ▸ | CDK1 | P06493 | 2/20 | 0.47 |
| ▸ | CDK4 | P11802 | 2/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.47 |
| ▸ | CCND1 | P24385 | 2/20 | 0.47 |
| ▸ | CDK2 | P24941 | 2/20 | 0.47 |
| ▸ | CCND3 | P30281 | 2/20 | 0.47 |
| ▸ | SGK1 | O00141 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12907457 | 0.87 | JAK2 (0.67) | PDPK1FGFR1FGFR2GSK3BFGFR3 | |
| SCHEMBL12907451 | 0.86 | FGFR1 (0.70) | PDPK1FGFR1FGFR2GSK3BFGFR3 | |
| SCHEMBL19188029 | 0.85 | JAK2 (0.57) | PDPK1JAK2CDK1CDK2ADORA2A | |
| SCHEMBL31552439 | 0.84 | ITK (0.53) | CHEK1ADORA2AADORA2BMAPK1MAP2K4 | |
| SCHEMBL12247 | 0.84 | ITK (0.53) | CHEK1ADORA2AADORA2BMAPK1MAP2K4 | |
| SCHEMBL6479941 | 0.84 | JAK2 (0.72) | PDPK1ABL1BCRJAK2CDK2 | |
| SCHEMBL12907438 | 0.83 | GSK3B (0.54) | PDPK1ABL1BCRFGFR1FGFR2 | |
| SCHEMBL12907468 | 0.83 | GSK3B (0.54) | PDPK1ABL1BCRFGFR1FGFR2 | |
| SCHEMBL13115653 | 0.82 | ABL1 (0.48) | PDPK1ABL1BCRFGFR1FGFR2 | |
| SCHEMBL12907422 | 0.82 | GSK3B (0.55) | PDPK1FGFR1FGFR2GSK3BFGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007115231-A2 | CXCR4 MODULATORS | CHEMOCENTRYX, INC. (US) | 2007-10-11 | — | — | WO | disclosed |