Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.54 |
| ▸ | ABL1 | P00519 | 2/20 | 0.52 |
| ▸ | BCR | P11274 | 2/20 | 0.52 |
| ▸ | PDPK1 | O15530 | 6/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.45 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.45 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | SGK1 | O00141 | 1/20 | 0.44 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4490310 | 0.84 | ABL1 (0.69) | GSK3BABL1BCRPDPK1JAK2 | |
| SCHEMBL14397096 | 0.83 | PDPK1 (0.53) | GSK3BABL1BCRPDPK1FGFR1 | |
| SCHEMBL12907457 | 0.81 | JAK2 (0.67) | GSK3BPDPK1FGFR1FGFR2FGFR3 | |
| SCHEMBL12907451 | 0.80 | FGFR1 (0.70) | GSK3BPDPK1FGFR1FGFR2FGFR3 | |
| SCHEMBL12907438 | 0.77 | GSK3B (0.54) | GSK3BABL1BCRPDPK1SMN1; SMN2 | |
| SCHEMBL12907465 | 0.76 | MAP2K4 (0.55) | GSK3BABL1BCRPDPK1FGFR1 | |
| SCHEMBL12907422 | 0.76 | GSK3B (0.55) | GSK3BPDPK1FGFR1FGFR2FGFR3 | |
| SCHEMBL12907464 | 0.75 | SGK1 (0.51) | PDPK1FGFR1FGFR2FGFR3JAK2 | |
| SCHEMBL12907471 | 0.75 | AAK1 (0.57) | GSK3BABL1BCRPDPK1FGFR1 | |
| SCHEMBL4483349 | 0.75 | GSK3B (0.74) | GSK3BABL1BCRFGFR1FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7872039-B2 | N-3-chlorobenzyl-3-amino-1H-indazole-5-carboxamide; 3-aminoindazoles; glucocorticoid-depedent kinase (SGK) inhibitors; SGK-induced diseases; diabetes, obesity, metabolic syndrome (dyslipidaemia), systemic and pulmonary hypertonia, cardiovascular diseases and renal diseases, fibrosis; inflammatory agents | MERCK PATENT GESELLSCHAFT (DE) | 2011-01-18 | — | — | US | disclosed |