Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.67 |
| ▸ | CHEK1 | O14757 | 6/20 | 0.56 |
| ▸ | AXL | P30530 | 1/20 | 0.55 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.53 |
| ▸ | PDPK1 | O15530 | 4/20 | 0.51 |
| ▸ | CDK4 | P11802 | 2/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.51 |
| ▸ | CCND1 | P24385 | 2/20 | 0.51 |
| ▸ | CDK2 | P24941 | 2/20 | 0.51 |
| ▸ | CCND3 | P30281 | 2/20 | 0.51 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 2/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.50 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.50 |
| ▸ | TTK | P33981 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | GSK3A | P49840 | 1/20 | 0.49 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.49 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12907469 | 0.88 | JAK2 (0.53) | JAK2CHEK1AXLMKNK1PDPK1 | |
| SCHEMBL14397096 | 0.87 | PDPK1 (0.53) | JAK2CHEK1AXLPDPK1CDK4 | |
| SCHEMBL27968550 | 0.86 | MKNK1 (0.71) | JAK2CHEK1AXLMKNK1CDK4 | |
| SCHEMBL12907451 | 0.84 | FGFR1 (0.70) | JAK2CHEK1PDPK1CDK2GSK3B | |
| SCHEMBL12907435 | 0.83 | CHEK1 (0.58) | JAK2CHEK1PDPK1CDK4CCNA2 | |
| SCHEMBL12907471 | 0.82 | AAK1 (0.57) | JAK2PDPK1GSK3BFGFR1FGFR2 | |
| SCHEMBL1513016 | 0.81 | FGFR1 (0.71) | JAK2CHEK1AXLMKNK1PDPK1 | |
| SCHEMBL12907438 | 0.81 | GSK3B (0.54) | JAK2CHEK1PDPK1CDK4CCNA2 | |
| SCHEMBL12907468 | 0.81 | GSK3B (0.54) | JAK2CHEK1PDPK1CDK4CCNA2 | |
| SCHEMBL12907422 | 0.80 | GSK3B (0.55) | JAK2CHEK1PDPK1CDK4CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7872039-B2 | N-3-chlorobenzyl-3-amino-1H-indazole-5-carboxamide; 3-aminoindazoles; glucocorticoid-depedent kinase (SGK) inhibitors; SGK-induced diseases; diabetes, obesity, metabolic syndrome (dyslipidaemia), systemic and pulmonary hypertonia, cardiovascular diseases and renal diseases, fibrosis; inflammatory agents | MERCK PATENT GESELLSCHAFT (DE) | 2011-01-18 | — | — | US | disclosed |