Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | TP53 | P04637 | 3/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1441710 | 0.92 | TP53 (0.61) | LMNAKDM4ETP53HPGDHSD17B10 | |
| SCHEMBL1440541 | 0.92 | TP53 (0.61) | LMNAKDM4ETP53HPGDHSD17B10 | |
| SCHEMBL1440237 | 0.89 | TP53 (0.64) | LMNAKDM4ETP53HPGDHSD17B10 | |
| SCHEMBL1440413 | 0.82 | TP53 (0.60) | LMNAKDM4ETP53HPGDHSD17B10 | |
| SCHEMBL1440380 | 0.80 | PTGES (0.58) | LMNAKDM4ETP53HPGDHSD17B10 | |
| SCHEMBL1439951 | 0.80 | MAPT (0.52) | LMNAKDM4ETP53HPGDHSD17B10 | |
| SCHEMBL1440223 | 0.79 | MAPT (0.52) | LMNAKDM4ETP53HPGDHSD17B10 | |
| SCHEMBL12811851 | 0.79 | LMNA (0.56) | LMNATP53MAPTPOLB | |
| SCHEMBL1440331 | 0.76 | TP53 (0.70) | LMNAKDM4ETP53HPGDHSD17B10 | |
| SCHEMBL1440810 | 0.76 | TP53 (0.48) | LMNATP53MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011023812-A1 | MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 (MPGES1) INHIBITORS | NOVASAID AB (SE) | 2011-03-03 | — | — | WO | disclosed |
| WO-2011023812-A1 | MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 (MPGES1) INHIBITORS | NOVASAID AB (SE) | 2011-03-03 | — | — | WO | disclosed |