Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12076349 | 0.92 | MAPT (0.52) | MAPTALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL1440241 | 0.91 | MAPT (0.53) | MAPTALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL1440354 | 0.91 | MAPT (0.53) | MAPTALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL1440521 | 0.89 | MAPT (0.55) | MAPTALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL1439951 | 0.84 | MAPT (0.52) | MAPTLMNAKDM4ETP53POLB | |
| SCHEMBL15474490 | 0.84 | MAPT (0.64) | MAPTLMNAMEN1KMT2ATP53 | |
| SCHEMBL1440037 | 0.79 | LMNA (0.63) | MAPTLMNAKDM4ETP53POLB | |
| SCHEMBL1440380 | 0.77 | PTGES (0.58) | MAPTALDH1A1LMNAKDM4ETP53 | |
| SCHEMBL1440776 | 0.75 | MAPT (0.55) | MAPTLMNAKDM4ETP53TRPV1 | |
| SCHEMBL1440170 | 0.75 | MAPT (0.55) | MAPTLMNAKDM4ETP53TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012117062-A1 | PIPERIDINYL BENZOIMIDAZOLE DERIVATIVES AS MPGES-1 INIHIBITORS | NOVASAID AB (SE) | 2012-09-07 | — | — | WO | disclosed |
| WO-2012117062-A1 | PIPERIDINYL BENZOIMIDAZOLE DERIVATIVES AS MPGES-1 INIHIBITORS | NOVASAID AB (SE) | 2012-09-07 | — | — | WO | disclosed |
| EP-2495244-A1 | Piperidinyl benzoimidazole derivatives as mPGEs-1 inhibitors | NovaSaid AB (SE) | 2012-09-05 | — | — | EP | disclosed |
| EP-2495244-A1 | Piperidinyl benzoimidazole derivatives as mPGEs-1 inhibitors | NovaSaid AB (SE) | 2012-09-05 | — | — | EP | disclosed |
| WO-2011023812-A1 | MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 (MPGES1) INHIBITORS | NOVASAID AB (SE) | 2011-03-03 | — | — | WO | disclosed |
| WO-2011023812-A1 | MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 (MPGES1) INHIBITORS | NOVASAID AB (SE) | 2011-03-03 | — | — | WO | disclosed |