Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 5/20 | 0.43 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.42 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.42 |
| ▸ | IDH2 | P48735 | 6/20 | 0.41 |
| ▸ | CTSC | P53634 | 3/20 | 0.41 |
| ▸ | CLK1 | P49759 | 3/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.41 |
| ▸ | ESYT2 | A0FGR8 | 2/20 | 0.41 |
| ▸ | NBAS | A2RRP1 | 2/20 | 0.41 |
| ▸ | CNOT1 | A5YKK6 | 2/20 | 0.41 |
| ▸ | TBKBP1 | A7MCY6 | 2/20 | 0.41 |
| ▸ | AGPS | O00116 | 2/20 | 0.41 |
| ▸ | MYO1F | O00160 | 2/20 | 0.41 |
| ▸ | SNAP23 | O00161 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL861455 | 0.84 | KIF11 (0.52) | KIF11KMT2AMEN1TSHRAURKA | |
| SCHEMBL827669 | 0.75 | IDH2 (0.47) | KIF11AURKAIDH2CTSCLMNA | |
| SCHEMBL13887208 | 0.72 | KIF11 (0.63) | KIF11KMT2AMEN1TSHRAURKA | |
| SCHEMBL5489647 | 0.70 | KIF11 (0.60) | KIF11KMT2AMEN1TSHRAURKA | |
| SCHEMBL9217042 | 0.69 | CTSC (0.44) | AURKAIDH2CTSC | |
| SCHEMBL827670 | 0.69 | AURKA (0.46) | AURKAIDH2CTSCMTORGSK3B | |
| SCHEMBL16332502 | 0.69 | FYN (0.65) | KIF11KMT2AMEN1TSHRAURKA | |
| SCHEMBL827730 | 0.68 | CLK1 (0.51) | KMT2AMEN1IDH2CLK1DYRK1A | |
| SCHEMBL9014180 | 0.67 | ABL1 (0.68) | KIF11AURKACTSCCLK1DYRK1A | |
| SCHEMBL21749289 | 0.66 | PDK2 (0.50) | FGFR1DDR2ALDH1A1MERTKPDK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007118903-A1 | TRISUBSTITUTED 1,2,4-TRIAZOLES | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-10-25 | — | — | WO | disclosed |