Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.52 |
| ▸ | CTSC | P53634 | 3/20 | 0.46 |
| ▸ | IDH2 | P48735 | 9/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.45 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.45 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | FLT4 | P35916 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 3/20 | 0.43 |
| ▸ | ESYT2 | A0FGR8 | 2/20 | 0.43 |
| ▸ | NBAS | A2RRP1 | 2/20 | 0.43 |
| ▸ | CNOT1 | A5YKK6 | 2/20 | 0.43 |
| ▸ | TBKBP1 | A7MCY6 | 2/20 | 0.43 |
| ▸ | AGPS | O00116 | 2/20 | 0.43 |
| ▸ | MYO1F | O00160 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL827669 | 0.90 | IDH2 (0.47) | KIF11CTSCIDH2MAPTKDR | |
| SCHEMBL9217042 | 0.85 | CTSC (0.44) | CTSCIDH2AURKA | |
| SCHEMBL14402632 | 0.84 | KIF11 (0.52) | KIF11CTSCIDH2MEN1KMT2A | |
| SCHEMBL827670 | 0.83 | AURKA (0.46) | CTSCIDH2KDRFLT1FLT4 | |
| SCHEMBL827730 | 0.80 | CLK1 (0.51) | IDH2MEN1KMT2AMAPTLMNA | |
| SCHEMBL827754 | 0.78 | IDH2 (0.46) | KIF11CTSCIDH2KDRFLT1 | |
| SCHEMBL827924 | 0.78 | IDH2 (0.44) | KIF11CTSCIDH2MAPTKDR | |
| SCHEMBL827571 | 0.78 | SMG1 (0.66) | CDK1BRAFAKT1MTORRAF1 | |
| SCHEMBL827744 | 0.77 | MAPT (0.47) | KIF11CTSCIDH2KMT2AMAPT | |
| SCHEMBL827752 | 0.77 | IDH2 (0.44) | KIF11CTSCIDH2MAPTKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143419-B2 | Trisubstituted 1,2,4-triazoles | JANSSEN PHARMACEUTICA N. V. (BE) | 2012-03-27 | — | — | US | disclosed |
| US-20090253691-A1 | TRISUBSTITUTED 1,2,4-TRIAZOLES | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-10-08 | — | — | US | disclosed |
| US-20090253691-A1 | TRISUBSTITUTED 1,2,4-TRIAZOLES | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-10-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090253691-A1 | TRISUBSTITUTED 1,2,4-TRIAZOLES | CHRNA1, CHRNA5, CHRNA3 | KIF11 3247/4885CTSC 1824/4885IDH2 3285/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.