Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.51 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 6/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1440776 | 0.89 | MAPT (0.55) | MAPTSLC6A9TRPV1LMNATP53 | |
| SCHEMBL1440170 | 0.85 | MAPT (0.55) | MAPTSLC6A9TRPV1LMNATP53 | |
| SCHEMBL1440241 | 0.84 | MAPT (0.53) | MAPTSLC6A9TRPV1LMNATP53 | |
| SCHEMBL1440323 | 0.83 | MAPT (0.56) | MAPTLMNATP53ALDH1A1 | |
| SCHEMBL12076349 | 0.83 | MAPT (0.52) | MAPTSLC6A9TRPV1LMNATP53 | |
| SCHEMBL1441710 | 0.80 | TP53 (0.61) | MAPTSLC6A9LMNATP53POLB | |
| SCHEMBL1440354 | 0.80 | MAPT (0.53) | MAPTSLC6A9TRPV1LMNATP53 | |
| SCHEMBL1439972 | 0.79 | SLC6A9 (0.51) | MAPTSLC6A9LMNATP53TRPC3 | |
| SCHEMBL1439951 | 0.79 | MAPT (0.52) | MAPTTRPV1LMNATP53TRPC3 | |
| SCHEMBL1440309 | 0.79 | MAPT (0.52) | MAPTSLC6A9LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011023812-A1 | MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 (MPGES1) INHIBITORS | NOVASAID AB (SE) | 2011-03-03 | — | — | WO | disclosed |