Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 1/20 | 0.51 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclopentanamine SCHEMBL1443414 | 0.93 | SLC6A9 (0.46) | SLC6A9EGLN1MAPTTRPC3NOTUM | |
| SCHEMBL1440170 | 0.90 | MAPT (0.55) | SLC6A9MAPTTRPC3LMNATP53 | |
| SCHEMBL1440776 | 0.90 | MAPT (0.55) | SLC6A9MAPTTRPC3LMNATP53 | |
| SCHEMBL1439951 | 0.84 | MAPT (0.52) | EGLN1MAPTTRPC3LMNANPY5R | |
| SCHEMBL1441243 | 0.84 | MAPT (0.52) | MAPTLMNATP53 | |
| SCHEMBL1440421 | 0.82 | PTGES (0.52) | MAPTLMNATP53 | |
| SCHEMBL1440521 | 0.82 | MAPT (0.55) | MAPTLMNATP53KDM4ENPSR1 | |
| SCHEMBL1440054 | 0.82 | PTGES (0.52) | MAPTLMNATP53HPGD | |
| SCHEMBL1440413 | 0.81 | TP53 (0.60) | MAPTLMNATP53KDM4EHPGD | |
| SCHEMBL1443417 | 0.80 | TP53 (0.44) | SLC6A9EGLN1MAPTTRPC3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012117062-A1 | PIPERIDINYL BENZOIMIDAZOLE DERIVATIVES AS MPGES-1 INIHIBITORS | NOVASAID AB (SE) | 2012-09-07 | — | — | WO | disclosed |
| WO-2012117062-A1 | PIPERIDINYL BENZOIMIDAZOLE DERIVATIVES AS MPGES-1 INIHIBITORS | NOVASAID AB (SE) | 2012-09-07 | — | — | WO | disclosed |
| EP-2495244-A1 | Piperidinyl benzoimidazole derivatives as mPGEs-1 inhibitors | NovaSaid AB (SE) | 2012-09-05 | — | — | EP | disclosed |
| EP-2495244-A1 | Piperidinyl benzoimidazole derivatives as mPGEs-1 inhibitors | NovaSaid AB (SE) | 2012-09-05 | — | — | EP | disclosed |
| WO-2011023812-A1 | MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 (MPGES1) INHIBITORS | NOVASAID AB (SE) | 2011-03-03 | — | — | WO | disclosed |
| WO-2011023812-A1 | MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 (MPGES1) INHIBITORS | NOVASAID AB (SE) | 2011-03-03 | — | — | WO | disclosed |