Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 17/20 | 0.60 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | TYK2 | P29597 | 3/20 | 0.47 |
| ▸ | JAK3 | P52333 | 3/20 | 0.47 |
| ▸ | JAK1 | P23458 | 3/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.43 |
| ▸ | CDC7 | O00311 | 2/20 | 0.43 |
| ▸ | PLK4 | O00444 | 2/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.43 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.43 |
| ▸ | CDK1 | P06493 | 2/20 | 0.43 |
| ▸ | ROS1 | P08922 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12292289 | 0.83 | PDPK1 (0.60) | JAK2PDPK1KDM4ECYP3A4GAA | |
| SCHEMBL10213929 | 0.78 | JAK2 (0.81) | JAK2PDPK1KDM4ECYP3A4GAA | |
| SCHEMBL118573 | 0.78 | JAK2 (0.64) | JAK2PDPK1KDM4ECYP3A4GAA | |
| SCHEMBL17680647 | 0.78 | JAK2 (0.36) | JAK2PDPK1KDM4ECYP3A4GAA | |
| SCHEMBL9909085 | 0.78 | ADORA2A (0.46) | JAK2PDPK1GSK3BNTRK1MAPK1 | |
| SCHEMBL18290033 | 0.78 | JAK2 (0.36) | JAK2PDPK1KDM4ECYP3A4GAA | |
| SCHEMBL14792020 | 0.77 | PRKAG1 (0.56) | — | |
| SCHEMBL24144678 | 0.75 | JAK2 (0.60) | JAK2PDPK1KDM4ECYP3A4GAA | |
| SCHEMBL6476445 | 0.75 | JAK2 (0.60) | JAK2PDPK1KDM4ECYP3A4GAA | |
| SCHEMBL10112094 | 0.75 | JAK2 (0.60) | JAK2PDPK1KDM4ECYP3A4GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007117465-A2 | INDAZOLE COMPOUNDS | ABBOTT LABORATORIES (US) | 2007-10-18 | — | — | WO | disclosed |