Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1440331 | 0.90 | TP53 (0.70) | TP53LMNAMAPTPOLB | |
| SCHEMBL1440413 | 0.87 | TP53 (0.60) | TP53LMNAMAPTPOLB | |
| SCHEMBL1440237 | 0.85 | TP53 (0.64) | TP53LMNAMAPTPOLB | |
| SCHEMBL1440520 | 0.79 | GAA (0.55) | TP53LMNAMAPTPOLB | |
| SCHEMBL1441710 | 0.79 | TP53 (0.61) | TP53LMNAMAPTPOLB | |
| SCHEMBL1440541 | 0.79 | TP53 (0.61) | TP53LMNAMAPTPOLB | |
| SCHEMBL1441243 | 0.78 | MAPT (0.52) | TP53LMNAMAPT | |
| SCHEMBL1439931 | 0.78 | PTGES (0.53) | TP53LMNAMAPTCYP3A4 | |
| SCHEMBL1440561 | 0.78 | TP53 (0.50) | TP53LMNAMAPTPOLB | |
| SCHEMBL1440521 | 0.77 | MAPT (0.55) | TP53LMNAMAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011023812-A1 | MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 (MPGES1) INHIBITORS | NOVASAID AB (SE) | 2011-03-03 | — | — | WO | disclosed |
| WO-2011023812-A1 | MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 (MPGES1) INHIBITORS | NOVASAID AB (SE) | 2011-03-03 | — | — | WO | disclosed |