⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6966711 | 0.81 | TDP1 (0.46) | — | |
| SCHEMBL11618596 | 0.80 | ALDH1A1 (0.50) | — | |
| SCHEMBL3670007 | 0.79 | — | — | |
| Acetic Acid Isobutyl Ester SCHEMBL28489463 | 0.79 | TSHR (0.60) | — | |
| SCHEMBL2906354 | 0.79 | TSHR (0.38) | — | |
| Acetic Acid Isobutyl Ester SCHEMBL6360200 | 0.79 | TSHR (0.60) | — | |
| SCHEMBL6046949 | 0.78 | TSHR (0.72) | — | |
| Acetic Acid Isobutyl Ester SCHEMBL22678 | 0.78 | — | — | |
| SCHEMBL9756912 | 0.78 | TDP1 (0.48) | — | |
| SCHEMBL11644788 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 83 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832082-B1 | N-HETEROARYL-PYRIDINESULFONAMIDE DERIVATIVES AND THEIR USE AS ENDOTHELIN ANTAGONISTS | ASTRAZENECA AB (SE) | 2001-11-21 | — | — | EP | claimed |
| EP-0832082-A1 | N-HETEROARYL-PYRIDINESULFONAMIDE DERIVATIVES AND THEIR USE AS ENDOTHELIN ANTAGONISTS | ZENECA LIMITED (GB) | 1998-04-01 | — | — | EP | claimed |
| WO-1996040681-A1 | N-HETEROARYL-PYRIDINESULFONAMIDE DERIVATIVES AND THEIR USE AS ENDOTHELIN ANTAGONISTS | ZENECA LIMITED (GB) | 1996-12-19 | — | — | WO | claimed |
| WO-2008065408-A9 | MODULATION OF PROSTAGLANDIN/CYCLOOXYGENASE METABOLIC PATHWAYS | HUNTER-FLEMING LIMITED (GB) | 2011-03-03 | — | — | WO | disclosed |
| EP-2097079-A2 | MODULATION OF PROSTAGLANDIN/CYCLOOXYGENASE METABOLIC PATHWAYS | Hunter-Fleming Limited (GB) | 2009-09-09 | — | — | EP | disclosed |
| WO-2008065408-A2 | MODULATION OF PROSTAGLANDIN/CYCLOOXYGENASE METABOLIC PATHWAYS | HUNTER-FLEMING LIMITED (GB) | 2008-06-05 | — | — | WO | disclosed |
| EP-1848426-A2 | TRICYCLIC CYTOPROTECTIVE COMPOUNDS | Hunter-Fleming Limited (GB) | 2007-10-31 | — | — | EP | disclosed |
| CN-1326853-C | 4- (2-furoyl) aminopiperidines, intermediates for the synthesis thereof, process for the preparation thereof and use thereof as medicaments | KYORIN SEIYAKU KK (JP) | 2007-07-18 | — | — | CN | disclosed |
| EP-1221440-B1 | Benzoheterocyclic derivatives useful as vasopressin or oxytocin modulators | OTSUKA PHARMA CO LTD (JP) | 2007-04-25 | — | — | EP | disclosed |
| WO-2006082409-A2 | TRICYCLIC CYTOPROTECTIVE COMPOUNDS | HUNTER-FLEMING LIMITED (GB) | 2006-08-10 | — | — | WO | disclosed |
| EP-1130017-B1 | Azole derivatives and their use as superoxide radical inhibitors | OTSUKA PHARMA CO LTD (JP) | 2005-06-15 | — | — | EP | disclosed |
| EP-0382185-A2 | Carbostyril derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1990-08-16 | — | — | EP | disclosed |
| US-4707476-A | TRANQUILIZERS | CIBA-GEIGY CORPORATION (US) | 1987-11-17 | — | — | US | disclosed |
| EP-0239129-A2 | Hydroquinoline compounds, compositions containing same and processes for preparing same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1987-09-30 | — | — | EP | disclosed |
| US-4492691-A | TRANSQUILIZERS, SEDATIVES | CIBA-GEIGY CORPORATION (US) | 1985-01-08 | — | — | US | disclosed |
| EP-0030916-B1 | AZATETRACYCLIC CARBONITRILES | CIBA-GEIGY AG (CH) | 1984-08-29 | — | — | EP | disclosed |
| EP-0030916-A1 | Azatetracyclic carbonitriles | CIBA-GEIGY AG (CH) | 1981-06-24 | — | — | EP | disclosed |
| US-4263315-A | TRANQUILLIZERS; SEDATIVES; ANTAGONIST FOR STIMULANTS | CIBA-GEIGY CORPORATION (US) | 1981-04-21 | — | — | US | disclosed |
| EP-0007450-A1 | Azatetracyclic carbonitriles, their preparation, pharmaceutical compositions containing them and their application | CIBA-GEIGY AG (CH) | 1980-02-06 | — | — | EP | disclosed |
| US-3996373-A | 2,3-Dihydro-1H-dibenz[e,g]isoindole compounds | CIBA-GEIGY CORPORATION (US) | 1976-12-07 | — | — | US | disclosed |