⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6966711 | 0.81 | TDP1 (0.46) | — | |
| SCHEMBL1440611 | 0.79 | — | — | |
| SCHEMBL198125 | 0.78 | TSHR (0.65) | — | |
| SCHEMBL14130601 | 0.78 | TDP1 (0.48) | — | |
| SCHEMBL8079639 | 0.78 | TDP1 (0.48) | — | |
| SCHEMBL304203 | 0.78 | TDP1 (0.54) | — | |
| SCHEMBL2152842 | 0.76 | — | — | |
| SCHEMBL2152767 | 0.76 | — | — | |
| SCHEMBL36039 | 0.76 | — | — | |
| SCHEMBL20237150 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 81 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080214660-A1 | Compounds and Methods for the Inhibition of the Expression of VCAM-1 | CRABTREE ACQUISITION CO, LLC | 2008-09-04 | — | — | US | claimed |
| US-20080176934-A1 | Use Of Diosmetin Compounds In The Treatment And Prevention Of Thrombotic Pathologies | LES LABORATOIRES SERVIER (FR) | 2008-07-24 | — | — | US | claimed |
| EP-1726582-A2 | Compounds and methods for the inhibition of the expression of vcam-1 | Atherogenics, Inc. (US) | 2006-11-29 | — | — | EP | claimed |
| EP-1695959-A1 | Compouds and methods for the inhibition of the expression of VCAM-1 | Atherogenics, Inc. (US) | 2006-08-30 | — | — | EP | claimed |
| US-20020177717-A1 | Compounds and methods for the inhibition of the expression of VCAM-1 | CRABTREE ACQUISITION CO, LLC | 2002-11-28 | — | — | US | claimed |
| US-6436919-B1 | LOCAL ANESTHETICS THAT HAVE LONGER DURATION OF ACTION WHILE REDUCING UNDESIRED SIDE EFFECTS | THERAVANCE INC. | 2002-08-20 | — | — | US | claimed |
| EP-1216243-A1 | QUINAZOLINONES AND ANALOGUES AND THEIR USE AS LOCAL ANESTHETICS | Advanced Medicine, Inc. (US) | 2002-06-26 | — | — | EP | claimed |
| WO-2001025234-A1 | QUINAZOLINONES AND ANALOGUES AND THEIR USE AS LOCAL ANESTHETICS | ADVANCED MEDICINE, INC. (US) | 2001-04-12 | — | — | WO | claimed |
| CN-1058494-C | New diosmetin compounds, a process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2000-11-15 | — | — | CN | claimed |
| EP-0994853-A2 | COMPOUNDS AND METHODS FOR THE INHIBITION OF THE EXPRESSION OF VCAM-1 | Atherogenics, Inc. (US) | 2000-04-26 | — | — | EP | claimed |
| EP-0709383-B1 | Diosmetin derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1999-12-15 | — | — | EP | claimed |
| WO-1998051662-A2 | COMPOUNDS AND METHODS FOR THE INHIBITION OF THE EXPRESSION OF VCAM-1 | ATHEROGENICS, INC. (US) | 1998-11-19 | — | — | WO | claimed |
| US-5629339-A | CHRONIC VENOUS INSUFFICIENCY | ADIR ET COMPAGNIE (FR) | 1997-05-13 | — | — | US | claimed |
| CN-1129701-A | New diosmetin compounds, a process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1996-08-28 | — | — | CN | claimed |
| US-4505923-A | GLAUCOMA | MERCK & CO., INC. (US) | 1985-03-19 | — | — | US | claimed |
| CN-112955115-B | Bioenergy glyceryl nicotinate, compositions and methods of using the same | 联合利华知识产权控股有限公司 | 2023-06-30 | — | — | CN | disclosed |
| EP-1454921-B1 | RADICAL POLYMERIZATION CATALYSTS AND ADHESIVE KIT FOR DENTAL USE | TOKUYAMA CORP (JP) | 2021-07-28 | — | — | EP | disclosed |
| EP-0056962-B1 | N-SUBSTITUTED POLYGLYCIDYL URAZOL COMPOUNDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Henkel Kommanditgesellschaft auf Aktien (DE) | 1985-10-02 | — | — | EP | disclosed |
| US-4393060-A | ANTICANCER | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 1983-07-12 | — | — | US | disclosed |
| EP-0056962-A2 | N-substituted polyglycidyl urazol compounds, process for their preparation and pharmaceutical compositions containing them | Henkel Kommanditgesellschaft auf Aktien (DE) | 1982-08-04 | — | — | EP | disclosed |